软组织内纤维组织细胞瘤28例形态学观察  

Histopathological alterations of fibrous histiocytoma located in subcutaneous soft tissue

作　　者：郭坚[1] 文国英[1] 张根娣[1] 

机构地区：[1]上海建工医院病理科,上海200083

出　　处：《诊断病理学杂志》2003年第3期141-143,i044,共4页Chinese Journal of Diagnostic Pathology

摘　　要：目的　探讨软组织内纤维组织细胞瘤 (FH)的病理形态特征。方法　用常规HE染色和免疫组化方法对2 8例FH进行观察分析 ,部分病例被随访。结果　男性 2 2例 ,女性 6例 ,平均 35岁。肿瘤好发于躯干 ,其次为四肢、头颈部 ,病变大多 <1cm。肿瘤由纤维母细胞样梭形细胞构成 ,呈束状。 2 5例 (89 3% )见局灶性storiform结构 ,19例 (6 7 9% )肿瘤内有裂隙形成 ;肿瘤可以有限地浸润周边脂肪和肌肉组织 ;肿瘤内的反应性成分如炎症细胞、泡沫细胞、多核巨细胞及含铁血黄素等不明显。肿瘤细胞Vim和SMA(+)。随访 15例无复发。结论　该类型FH具有与一般皮肤FH相同的基本组织结构及其自身的组织学特点 ,应与软组织梭形细胞增生性病变及肿瘤相鉴别。Objective To study the histopathological features of fibrous histiocytoma (FH) located in subcutaneous soft tissues. Methods Total 28 cases were analyzed with conventional H-E stain and immunohistochemical technique, and followed-up in some cases. Results The patients were composed of 22 male and 6 female, aged 35 years in average. The most common site of lesions was in trunks, and the next prevailing sites were extremeties and head-necks. Usually the diameter of tumor was less than 1 cm. Microscopically, the tumor consisted of the fibroblast-like spindle cells arranged in fascicular pattern. Additional prominent features in morphology included ① a storiform structure in focal areas was found in 25 cases (89.3%); ② the clefts within tumor were seen in 19 cases (67.9%); ③ the tumor infiltrated into peripheral adipose and muscular tissues; ④ the mild reactive elements such as inflammatory cells, foam cells, multinuclear giant cells and hemosiderrin were also observed. Immunohistochemical study showed that neoplastic cells expressed Vim and SMA. 15 patients with followed-up were no recurrence. Conclusion This variant of FH is similar to ordinary cutaneous FH in basic histologic structure, but have some prominent features.

关 键 词：软组织 纤维组织细胞瘤 形态学观察 病理形态特征 免疫组化 HE染色 

分 类 号：R730.262[医药卫生—肿瘤]