nm23 mRNA表达与肺癌的分化转移及病理之间的相关性研究  

The Relationship Between nm23 mRNA Expression and the Differentiation, Metastasis and Pathology of Lung Cancer

作　　者：王海峰[1] 陈晓峰[1] 高文[1] 丁嘉安[1] 易祥华[1] 史德刚[1] 

机构地区：[1]上海市肺科医院胸外科,上海200433

出　　处：《中国临床医学》2004年第1期24-27,共4页Chinese Journal of Clinical Medicine

基　　金：上海市卫生局科技发展基金 (9942 4)资助

摘　　要：目的 :研究肺癌中nm2 3mRNA表达水平与肺癌病理分级和临床分期之间的关系。方法 :5 3例肺癌标本 ,4 6例 (癌旁 )正常肺组织 ,5例肺部良性结节性病变组织 ,用RT -PCR方法检测标本中nm2 3mRNA的表达水平 ,根据手术、病理和影像学结果判断有无转移并确定分期 ,就nm2 3mRNA表达水平与临床变量之间进行分析。结果 :nm2 3mRNA在肺癌和 (癌旁 )正常肺组织中的阳性率分别为 4 3.4 % ( 2 3/ 5 3)和 39.1% ( 18/ 4 6 ) ,P >0 .0 5 ;低分化、晚期、肺门纵隔淋巴结转移的非小细胞肺癌 ,其nm2 3mRNA的表达量显著降低 (P <0 .0 5 )。结论 :nm2 3mRNA与肺癌的分化、转移及病理分期有关 ,检测nm2 3mRObjective: To investigate the relationship between the level of nm23 mRNA expression and pathological grades and clinical stages of lung cancer.Methods:We collected 53 specimens of lung cancer, 46 of (para-cancer) normal lung tissues, 5 of benign nodal lung diseases. We used RT-PCR to measure the level of nm23 mRNA expression in the specimens, and determine the stages of disease according to the results of surgery, pathology and imaging diagnoses. Then analyses were carried out between the level of nm23 mRNA expression and the clinical variables.Results: 43.4%(23/53) and 39.1%(18/46) specimens of lung cancer and (para-cancer) normal lung tissue were positive for nm23 mRNA expression, P >0.05; non-small cell lung cancer with low differentiation, advanced stages and nodal metastases showed a magnificently lower expression of nm23 mRNA ( P <0.05). Conclusion:nm23 mRNA expression is related to the differentiation, metastases and pathological staging of lung cancer, hence, might affect its prognosis.

关 键 词：NM23基因 MRNA表达 肺癌 分化转移 病理相关性 分子生物学 

分 类 号：R734.2[医药卫生—肿瘤]