Effect of electrolyzed oxidizing water and hydrocolloid occlusive dressings on excised burn-wounds in rats  

作　　者：辛华 郑雅娟 中永士师明 韩振国 

机构地区：[1]Department of Thoracic Surgery,China-Japan Union Hospital,Jilin University,Jilin 130031,China [2]Department of Ophthalmology,Second Clinical Hospital, Jilin University,Jilin 130041,China [3]Department of Emergency and Critical Care Medicine, Akita University School of Medicine,Akita 010-8543,Japan [4]Department of Thoracic Surgery,China-Japan Union Hospital,Jilin University,Jilin 130031,Chinabjective: To study the efficacy of electrolyzed oxidizing water ( EOW ) and hydrocolloid occlusive dressings in the acceleration of epithelialization in excised burn-wounds in rats.Methods: Each of the anesthetized Sprague-Dawley rats (n = 28) was subjected to a third-degree burn that covered approximately 10% of the total body surface area. Rats were assigned into four groups: Group Ⅰ( no irrigation), Group Ⅱ(irrigation with physiologic saline), Group Ⅲ( irrigation with EOW ) and Group Ⅳ( hydrocolloid occlusive dressing after EOW irrigation). Wounds were observed macroscopically until complete epithelialization was present, then the epithelialized wounds were examined microscopically. Results: Healing of the burn wounds was the fastest in Group Ⅳtreated with hydrocolloid occlusive dressing together with EOW. Although extensive regenerative epidermis was seen in each Group, the proliferations of lymphocytes and macrophages associated with dense collagen deposition were more extensive in Group Ⅱ, Ⅲand IV than in Group Ⅰ. These findings were particularly evident in Group Ⅲand Ⅳ.Conclusions: Wound Healing may be accelerated by applying a hydrocolloid occlusive dressing on burn surfaces after they are cleaned with EOW.

出　　处：《Chinese Journal of Traumatology》2003年第4期234-237,共4页中华创伤杂志（英文版）

基　　金：This study was supported by the Ministry of Education, Science,Sports and Culture of Japan(No.10470311).

摘　　要：Objective: To study the efficacy of electrolyzed oxidizing water ( EOW ) and hydrocolloid occlusive dressings in the acceleration of epithelialization in excised burn-wounds in rats.Methods: Each of the anesthetized Sprague-Dawley rats (n = 28) was subjected to a third-degree burn that covered approximately 10% of the total body surface area. Rats were assigned into four groups: Group Ⅰ ( no irrigation), Group Ⅱ (irrigation with physiologic saline), Group Ⅲ ( irrigation with EOW ) and Group Ⅳ ( hydrocolloid occlusive dressing after EOW irrigation). Wounds were observed macroscopically until complete epithelialization was present, then the epithelialized wounds were examined microscopically. Results: Healing of the burn wounds was the fastest in Group Ⅳ treated with hydrocolloid occlusive dressing together with EOW. Although extensive regenerative epidermis was seen in each Group, the proliferations of lymphocytes and macrophages associated with dense collagen deposition were more extensive in Group Ⅱ, Ⅲ and IV than in Group Ⅰ. These findings were particularly evident in Group Ⅲ and Ⅳ.Conclusions: Wound Healing may be accelerated by applying a hydrocolloid occlusive dressing on burn surfaces after they are cleaned with EOW.

关 键 词：Occlusive dressings Wounds and injuries COLLOIDS EPITHELIUM Electrolyzed oxidizing water 

分 类 号：R644[医药卫生—外科学]