血管瘤与血管内皮细胞活性因子关系的探讨  

Study on the Relationship Between the Development of Hemangioma and Vascular Endothelial Active Factors

作　　者：韩丽娜[1] 顾瑛[1] 刘凡光[1] 

机构地区：[1]解放军总医院激光科,100853

出　　处：《放射免疫学杂志》2004年第2期81-82,共2页Journal of Radioimmanology

摘　　要：目的 :探讨血管瘤与内皮素 1 (ET - 1 )、一氧化氮 (NO)和细胞间粘附分子 1 (ICAM - 1 )等血管内皮细胞活性因子的相互关系。方法 :选择 6 0例血管瘤患者 ,手术切除瘤体组织和周围少量正常组织 ,行HE染色 ,分为血管瘤增殖期和退化期两实验组。采用放射免疫分析检测血管瘤体和正常组织内ET - 1 ,采用酶联免疫分析检测细胞间粘附分子 1 (ICAM - 1 ) ,采用Geriss法检测血浆NO水平。结果 :增殖期血管瘤较周围正常组织高水平表达ET - 1和ICAM - 1 ,低水平表达NO。退化期血管瘤瘤体ET - 1、ICAM - 1和NO水平同周围正常组织无明显改变。结论 :血管瘤的发生发展同血管内皮细胞活性因子密切相关 ,ET - 1、ICAM - 1和NO等血管活性因子的检测有助于血管瘤发病机制的探讨。Objective To investigate the relationship between the development of hemangioma and the expression of the vascular endothelial active factors Endothelin-1 (ET-1), Nitric oxide (NO) and Intercellular adhesion molecule-1 (ICAM-1). Methods The hemangioma proper with some adjacent normal tissue were excised in 60 patients and were pathologically identified as of two groups: proliferative phase and involution phase. The contents of ET-1, ICAM-1 and NO in the hemangioma proper and surrounding normal tissue were determined with RIA, ELISA and Griss method respectively. Results Hemangioumas of the proliferative phase had higher contents of ET-1, ICAM-1 and lower contents of NO than those in the normal tissue ( p <0 05). In the involution phase, there were no significant differences. Conclusion The vascular endothelial active factors plasyed important roles in the development of hemangiomas.

关 键 词：血管瘤 血管内皮细胞 活性因子 ET-1 NO 内皮素1 一氧化氮 

分 类 号：R732.2[医药卫生—肿瘤]