DNA拓扑异构酶在人体组织的分布及其与肿瘤的关系  

THE DISTRIBUTION OF TOPOISOMERASES ACTIVITIES IN NOMAL HUMAN TISSUES AND THE CORRELATION WITH THOSE IN TUMOR TISSUES

作　　者：柴青[1] 王理开[1] 徐晓利[1] 

机构地区：[1]中山医科大学生物化学教研室

出　　处：《中山医科大学学报》1992年第2期45-48,共4页Academic Journal of Sun Yat-sen University of Medical Sciences

摘　　要：作者检测了人体多种组织器官及相应肿瘤组织的拓扑酶Ⅰ及Ⅱ的活力,结果表明,除睾丸组织拓扑酶Ⅰ和Ⅱ活力显著高于其它组织外,其余各组织拓扑酶Ⅰ和Ⅱ的活力水平基本一致;肿瘤组织与非肿瘤组织拓扑酶Ⅰ活力无明显差异;恶性肿瘤组织的拓扑酶Ⅱ活力较良性肿瘤及非肿瘤组织明显升高。DNA toposicmerases have been found to have an important role in genetic events. In order to explore the biological function of the enzymes, authors studied the distribution and specific activities of DNA topoisomerases in some organs of the human body and their malignant tissues; and discovered that the activities of DNA topoisomerase Ⅰ and Ⅱ existed in all of human organs and their malignant tissues including liver, lungs, kidney, stomach, brain, bladder, thyroid, prostate, testicle. There was no significant difference of the activities of DNA toposiomerase Ⅰ between normal tissues and malignant tissues except testicle in which the activities of DNA topoisomerase Ⅰ and Ⅱ were higher than those of other tissues. The specific activities of DNA topoisomerase I were much higher in malignant tissues than those in normal tissues.

关 键 词：DNA 拓扑异构酶 人体组织 肿瘤 

分 类 号：R73－34[医药卫生—肿瘤]