艾素联合方案治疗中晚期鼻咽癌17例疗效观察  

Clinical investigation of aisui in recombination inducer chemotherapy for17case of nasopharyngeal neoplasms

作　　者：吴新光[1] 陆小军[1] 雷风[1] 刘玉猛[1] 叶奕菁[1] 何伟基[1] 周锡刚[1] 

机构地区：[1]中山市人民医院肿瘤科,广东中山528403

出　　处：《现代医药卫生》2004年第8期616-617,共2页Journal of Modern Medicine & Health

摘　　要：目的 :观察艾素 (docetaxle,DOC) ,氟脲嘧啶 (5 -FU)、顺铂 (DDP)联合方案治疗中晚期鼻咽癌 (NPC)的临床疗效及毒副反应。方法 :诱导性治疗中晚期鼻咽癌患者17例 ,DOC75mg/ 静脉滴注 ,滴1小时 ,第1天 ;5 -FU500mg/ 静脉滴注 ,第1～5天 ;DDP20mg/ 静脉滴注第1～5天 ;3周为一疗程 (DFP方案 )。结果 :总有效率反应为骨髓抑制 ,Ⅱ～Ⅲ度白细胞减少占41 2 % ,Ⅱ～Ⅲ度血小板下降占11 8 % ,非血液毒性轻微。结论 :DFP联合方案治疗中晚期鼻咽癌患者具有使用简便 ,有效率高和可耐受的特点 ,值得临床进一步研究。Objective:To observe the response rate and toxicity of DFP regemen induction chemotherapy for patients with advanced naˉsopharyneal carcinona.Methods:A total of17patients with advanced nasopharyneal carcinoma were included in this study.Docetaxel75mg/was given through intravenous dripping for1hour on the first Day,5-FU500mg/and cispltin20mg/ were given through intravenous dripping fromthe first day to the fifth day.The courses were repeated every3weeks for2cycles(DFP).Results:The response rate waas100%(7cases were overall response,10cases were partial response).The main toxicity was hematological;GradeⅡ～Ⅲ.the incidence of leocopenia was41.2%,gradeⅡ～Ⅲthe incidence of thrombocytopeia was11.8%.The nonhematological toxicity was mild.Conclusion:The features of the DFP regimen in curing the patients with advanced nasopharyneal carcinoma are convenience,high effectiveness and mid toxicity.It is worthy further clinical studies.

关 键 词：艾素 治疗 中晚期 鼻咽癌 疗效观察 氟脲嘧啶 顺铂 联合方案 

分 类 号：R739.62[医药卫生—肿瘤]