Molecular phylogeny of coronaviruses including human SARS-CoV  

作　　者：GAOLei QIJi WEIHaibin SUNYigang HAOBailin 

机构地区：[1]InstituteofTheoreticalPhysics,ChineseAcademyofSciences,Beijing100080,China [2]T-LifeResearchCenter,FudanUniversity,Shanghai200433,China [3]GraduateSchool,ZhejiangUniversity,Hangzhou310027,China [4]HangzhouBranch,BeijingGenomicsInstitute,ChineseAcademyofSciences,Hangzhou310008,China

出　　处：《Chinese Science Bulletin》2003年第2期1170-1174,共5页

基　　金：国家自然科学基金，中国科学院知识创新工程项目

摘　　要：Phylogenetic tree of coronaviruses (CoVs) including the human SARS-associated virus is reconstructed from complete genomes by using our newly developed K- string composition approach. The relation of the human SARS-CoV to other coronaviruses, i.e. the rooting of the tree is suggested by choosing an appropriate outgroup. SARS-CoV makes a separate group closer but still distant from G2 (CoVs in mammalian host). The relation between different isolates of the human SARS virus is inferred by first constructing an ultrametric distance matrix from counting sequence variations in the genomes. The resulting tree is consistent with clinic relations between the SARS-CoV isolates. In addition to a larger variety of coronavirus genomes these results provide phylogenetic knowledge based on independent novel methodology as compared to recent phylogenetic studies on SARS-CoV.

关 键 词：分子发生学 人体冠状病毒 SARS 合成距离 系统发生树 

分 类 号：R373.1[医药卫生—病原生物学]