Study of ionizable drugs transfer across the water／1,2-dichloroethane interface with phase volume ratio equal to unity using a three-electrode system  

作　　者：ZHANGMeiqin SUNPeng CHENYong LIFei GAOZhao SHAOYuanhua 

机构地区：[1]StateKeyLaboratoryofElectroanalyticalChemistry,ChangchunInstituteofAppliedChemistry,ChineseAcademyofSciences,Changchun130022,China [2]CollegeofChemistryandMolecularEngineering,PekingUniversity,Beijing100871,China

出　　处：《Chinese Science Bulletin》2003年第2期1234-1239,共6页

基　　金：国家自然科学基金，国家自然科学基金，面向21世纪教育振兴行动计划(985计划)

摘　　要：The electrochemical behavior of ionizable drugs (Amitriptyline, Diphenhydramine and Trihexyphene- dyl) at the water/1,2-dichloroethane interface with the phase volume ratio (r = Vo/Vw) equal to 1 are investigated by cyclic voltammetry. The system is composed of an aqueous droplet supported at an Ag/AgCl disk electrode and it was covered with an organic solution. In this manner, a conventional three-electrode potentiostat can be used to study the ionizable drugs transfer process at a liquid/liquid interface. Physicochemical parameters such as the formal transfer potential, the Gibbs energy of transfer and the standard partition coefficients of the ionized forms of these drugs can be evaluated from cyclic voltammograms obtained. The obtained results have been summarized in ionic partition diagrams, which are a useful tool for predicting and interpreting the transfer mechanisms of ionizable drugs at the liquid/liquid interfaces and biological membranes.The electrochemical behavior of ionizable drugs (Amitriptyline, Diphenhydramine and Trihexyphene- dyl) at the water/1,2-dichloroethane interface with the phase volume ratio (r = Vo/Vw) equal to 1 are investigated by cyclic voltammetry. The system is composed of an aqueous droplet supported at an Ag/AgCl disk electrode and it was covered with an organic solution. In this manner, a conventional three-electrode potentiostat can be used to study the ioni-zable drugs transfer process at a liquid/liquid interface. Physicochemical parameters such as the formal transfer potential, the Gibbs energy of transfer and the standard par-tition coefficients of the ionized forms of these drugs can be evaluated from cyclic voltammograms obtained. The ob-tained results have been summarized in ionic partition dia-grams, which are a useful tool for predicting and interpret-ing the transfer mechanisms of ionizable drugs at the liq-uid/liquid interfaces and biological membranes.

关 键 词：电离药物转移 水 1 2-二氯乙烷 三电极系统 电化学行为 界面化学 ITIES 非互溶电解液 

分 类 号：R914[医药卫生—药物化学] O646.5[医药卫生—药学]