卵巢肝样癌1例报道并文献复习  

Hepatoid carcinoma of ovary: a case report and review of literature

作　　者：束木娟[1] 张廷璆[2] 金嘉平[1] 

机构地区：[1]上海第二医科大学附属第九人民医院病理科,上海200011 [2]复旦大学附属肿瘤医院病理科,上海200032

出　　处：《诊断病理学杂志》2004年第1期33-34,I008,共3页Chinese Journal of Diagnostic Pathology

摘　　要：目的　探讨卵巢肝样癌的病理学特点、诊断及鉴别诊断。方法　对 1例卵巢肝样癌进行光镜、免疫组化检测。结果　卵巢肿瘤由类似肝细胞癌样的细胞组成 ,排列呈片状、巢状 ,瘤细胞体积大 ,胞质丰富 ,嗜酸性 ,胞核圆形、卵圆形位于中央 ,可见核仁 ,分裂象活跃。AFP(+ )、HCG(+ /-) ,而CA 12 5、CEA、CK、EMA、Inhibin、ER、PR、Mac3 87、KP 1和HMB45均 (-)。CD3 4显示丰富的毛细血管。PAS(-)。结论　卵巢肝样癌是一种非常罕见的恶性肿瘤 ,组织学形态需与肝样卵黄囊瘤、类固醇细胞瘤或脂质细胞瘤、卵巢转移性肝细胞癌。ObjectiveTo study the pathological features, diagnosis and differential diagnosis of hepatoid carcinoma of the ovary MethodsA case of hepatoid carcinoma of the ovary was examined with light microscopy and immunohistochemistry and literature was reviewed ResultsThe tumor was composed of cells resembling those of hepatocellular carcinoma The tumor cells were arranged in sheets and in nest pattern The cells had abundant eosinophilic cytoplasm and round to ovoid, central n uclei, with visual nucleoli and active mitoses Immunohistochemically, the tumor c ells were positive for AFP, weakly positive for HCG, and negative for CA-125, CEA, CK, EMA, inhibin, ER, PR, Mac387, KP-1, and HMB45 Special staining of PAS was negative intracellularly and extrecellularly in the tumor ConclusionsHepatoid carcinoma of the ovary is a very rare hi gh-grade malignant tumor Differential diagnostic considerations of the tumor s hould include hepatoid yolk sac tumor, steroid cell (lipid cell) tumors, hepatocel lular carcinoma and malignant melanoma metastatic to the ovary

关 键 词：卵巢肝样癌 文献复习 病理学特点 诊断 鉴别诊断 甲胎蛋白 

分 类 号：R737.31[医药卫生—肿瘤]