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作 者:陈立平[1] 夏阳[1] 王银平[2] 张俊阁[2] 崔丽[3] 潘力[3] 邱铁东[3]
机构地区:[1]吉林大学第二医院病理科,长春130041 [2]吉林大学第一医院病理科,长春130021 [3]吉林大学基础医学院,长春130000
出 处:《诊断病理学杂志》2004年第1期23-25,I006,共4页Chinese Journal of Diagnostic Pathology
摘 要:目的 探讨小脑血管母细胞瘤的临床病理特征及间质细胞的起源 ,以提供病理诊断和鉴别诊断依据。方法 对 11例小脑血管母细胞瘤进行组织形态观察及NSE、lysozyme、AAT、AACT、GFAP、S 10 0、desmin、EMA、CD3 4、CK免疫组化标记 ,对其中 1例做了电镜观察。结果 11例中发生于左小脑半球 3例 ,右小脑半球 6例 ,小脑蚓部 2例 ;表现为高颅压者 9例 ,共济失调者 6例 ;两者同时存在者 6例。肿瘤间质细胞NSE、lysozyme、AAT、AACT、GFAP、S 10 0、desmin全部或部分 (+ ) ;而EMA、CD3 4、CK(-)。电镜未见特异性改变。结论 血管母细胞瘤是一种好发于成人小脑部位的良性肿瘤 ,肿瘤的间质细胞有神经内分泌分化能力 。ObjectiveTo study the clinicopathological feature s and histogenesis of the stromal cells of hemangioblastoma in cerebellum MethodsThe paraffin-embbeded sections of 11 cases were stained immunohistochemically for NSE, lysozyme, AAT,AACT, GFAP, S- 100, desmin, EMA, CD34, and CK, and one of them was observed by transmission-elec tron microscopy ResultsThe patients ranged from 23 to 60 years old (average 41 7) Three of 11 cases were located in left lobe of the cerebella, a nd six in right lobe, and two in the cerebellar vermis The symptoms of intracranial h ypertension occurred in 9 cases (82%), dystonic movement in 6 cases (56%), and both in 6 cases The stromal cells were positive for NSE, lysozyme, AAT, AACT, GFAP, S-100, and desmin, and negative for EMA, CD34 and CK There was no evident special change in the ultrastructural observition ConclusionsHemagioblastoma is a benign tumor which occurs commonly in adult. The st romal cells is positive for neuroendocrine markers, which suggests that the tumor may be originated from neuroendocrine system
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