急性脑血管病患者血清hs-CRP,TNF-α和IL-6的动态变化及临床意义  

Dynamic changes of serum hs-CRP, TNF-α, IL-6 in acute cerebral vessel disease patients and their clinical significance

作　　者：曹姣妃[1] 刘宁[1] 梁德胜[1] 裴世澄[1] 

机构地区：[1]兰州医学院第二附属医院神经内科,甘肃兰州730030

出　　处：《第四军医大学学报》2004年第2期173-175,共3页Journal of the Fourth Military Medical University

摘　　要：目的 :动态观察急性脑血管病 (ACVD)患者血清hs CRP ,TNF α,IL 6的水平变化 ,探讨ACVD患者可能存在炎症/免疫功能紊乱 .方法 :采用ELISA法测hs CRP ,放免法测TNF α ,IL 6含量 .对 70例ACVD患者在发病第 1 ,3,7,1 5日进行动态检测 ,同时测定 30例年龄相匹配的健康人血清值作为正常对照 .将每项指标的每个时相值同正常对照组间、同一时相间以及不同指标间进行配对t检验、方差分析及相关分析 .结果 :ACVD患者发病第 1 ,3日上述指标均高于对照组 (P <0 .0 1 ) ,第 7日下降 ,第 1 5日基本恢复正常 .在早期hs CRP ,TNF α,IL 6三者在同一个时相两两之间呈正相关性 (r>0 .5 ,P <0 .0 5 ) .结论 :hs CRP ,TNF α,IL 6作为促炎因子参与了ACVD的发生发展过程 ,提示hs CRP ,TNF α ,ILAIM: To study the dynamic changes of serum high sensitivity C reactive protein (hs CRP), interleukin 6 (IL 6) and tumor necrosis factor α (TNF α), which lead to inflammatory and/or immunological dysfunctions in the patients suffering from acute cerebral vessel disease (ACVD). METHODS: Serum hs CRP level detected by ELISA and TNF α and IL 6 levels detected by RIA were determined at the 1 st , 3 rd , 7 th and 15 th d from 70 ACVD patients and from 30 age matching healthy persons as control. Data of each parameter investigated were analyzed for statistical difference between cases and control group by t test, and correlation between the levels of the markers at different times were compared. Analysis of variance(ANOVA) was performed on sample means. RESULTS: Levels of serum hs CRP, IL 6 and TNF α at the 1 st and 3 rd d of cases were higher than those of the control group ( P < 0.01), but decreased at the 7 th d and restored to normal at the 15 th d. These three markers were positively correlated to the early stage of ACVD as well as stroke severity( r>0.5, P < 0.05). CONCLUSION: Hs CRP, IL 6 and TNF α participate in initiation and propagation steps of ACVD. It inferred that the respective antagonists of hs CRP, IL 6 and TNF α may possess a high potential as the treatment strategy for ACVD.

关 键 词：急性病 脑血管意外 C反应蛋白 肿瘤坏死因子 白细胞介素6 

分 类 号：R743.3[医药卫生—神经病学与精神病学]