溶血性尿毒症综合征的超微结构研究  

Ultrastructural study of hemalytic-uremic syndrome

作　　者：朱平[1] 杨洁[1] 张岚[1] 陈新宇[1] 田烨[1] 

机构地区：[1]上海第二医科大学细胞生物学教研室,上海200025

出　　处：《电子显微学报》2004年第1期22-27,共6页Journal of Chinese Electron Microscopy Society

摘　　要：应用透射电镜观察溶血性尿毒症综合征(HUS)肾活检组织,结果显示:HUS以肾小球毛细血管内皮细胞增生、肿胀,内皮下间隙增宽伴电子透明的疏松物质(electron lucent,"fluffy")沉积以及管腔内微血栓形成为主要病变特点。内皮下间隙增宽和电子透明的疏松物质沉积是HUS电镜下的特征性结构,对其诊断具有决定性作用。肾活检电镜检查不仅有助于HUS的诊断,同时也是判断预后的主要指标。本文结合文献复习讨论了HUS的鉴别诊断、病因和发病机制。Renal biopsies with hemolytic-uremic syndrome were studied by electron microscopy.The result showed that the characteristic ultrastructural changes were the proliferation and swelling of the glomerular endothelial cells; electron-lucent'fluffy'material filling in the space between the GBM and the formation of microthrombus. The electron microscopic study of renal tissue plays an important role in HUS diagnosis. The differential diagnosis, etiology and pathogenesis of HUS were discussed.

关 键 词：溶血性尿毒症综合征 超微结构 内皮细胞 透射电镜诊断 肾功能衰竭 

分 类 号：R361[医药卫生—病理学]