肝细胞癌患者血清TT病毒感染检测分析  

Investigation on the prevalence of TT virus infection in sera of patients with hepatocellular carcinoma

作　　者：张弘[1] 江枫[1] 魏群[1] 周国雄[1] 黄介飞[1] 

机构地区：[1]南通医学院附属医院消化病研究室,226001

出　　处：《实用肝脏病杂志》2004年第2期97-98,共2页Journal of Practical Hepatology

摘　　要：目的　调查TT病毒在肝细胞癌患者及南通地区正常人群中的感染状况。方法　采用巢式聚合酶链反应(n PCR)法 ,对 14 5例肝细胞癌患者、14 3例献血员和 3 75例体检者血清进行了检测分析。结果　 14 5例肝细胞肝癌患者中有 48例TTVDNA阳性 ( 3 3 .1%) ,献血员中有 13例TT病毒DNA阳性 ( 9.1%) ,正常体检人群中有 3 9例TT病毒DNA阳性 ( 10 .4%)。肝细胞癌患者中TT病毒感染率明显高于献血员和正常人群。结论　TT病毒与肝细胞癌发生有一定的关系 。Objective To investigate the prevalence of TT virus infection in ordinary people or patients with hepatocellular carcinoma. Methods TT virus infection was detected by nested polymerase chain reaction in 375 normal population , 143 blood donors and 145 hepatocellular carcinoma . Results The positive rate of TTV DNA was 33.1%(48/145)in patients with hepatocellular carcinoma ,while 10.4%(39/375) in normal population and 9.1%(13/143)in donor specimens. There were significant differences in the positive rates between hepatocellular carcinoma and normal population or donors. Conclusions There are some relationship in TT virus and hepatocellular carcinoma, which means TT virus is one of the dangerous factors in human hepatic carcinogenesis.

关 键 词：肝细胞癌 血清 TT病毒感染 检测 诊断 

分 类 号：R735.7[医药卫生—肿瘤]