凋亡抑制因子survivin在喉鳞癌中表达及其临床意义  

Expression of Apoptosis Inhibitor Survivin in Laryngeal Carcinoma Cells and Clinical Significance of Expressed Product

作　　者：李春晖[1] 马忠恕[1] 肖光[2] 张岩[1] 

机构地区：[1]吉林大学第一临床医院,长春130021 [2]解放军第二零八医院,长春130062

出　　处：《中国生物制品学杂志》2004年第2期110-112,共3页Chinese Journal of Biologicals

摘　　要：目的　探讨凋亡抑制因子survivin在喉鳞癌中的表达及临床意义。方法　应用免疫组化SABC方法检测 5 4例喉鳞癌手术切除标本石蜡切片组织中survivin的表达 ,并以 10例声带息肉组织为对照。结果　survivin在声带息肉中不表达 ;在 5 4例喉鳞癌中 ,38例 ( 70 .4 % )表达阳性 ;survivin阳性表达率与喉癌患者的年龄、性别、肿瘤大小、临床分型无相关性 (P >0 .0 5 ) ,与喉癌临床分期、组织学分级、淋巴结转移呈正相关 (P <0 .0 5 )。结论　凋亡抑制因子survivin的异常表达所引起的凋亡抑制与喉鳞癌的发生发展相关 ,可作为肿瘤诊断、预后和治疗的一个新指标。Objective To explore the expression of apoptosis inhibitor surviving,an apoptosis inhibitor,in laryngeal carcinoma cells and the clinical significance of expressed product.Methods Detect the expression of survivin in 54 tissue sections of laryngeal carcinoma speciens,by immunohistochemical methed using 10 specimens from the patients with polyp of vocal cord as control.Results No survivin was detected in polyp of vocal cord.However,it was detected in 38 of 54(70.4%)specimens from the patients with laryngeal carcinoma.The survivin expression was unrelated to the ages and sexes of patients or the sizes of tumors( P> 0.05 ),but positively related to the clinical stages,histological grades and lymphatic metastasis of the tumor.Conclusion The apoptosis inhibition caused by the abnormal expression of survivin was related to the onset and progression of laryngeal carcinoma.So the expression of survivin may be used as a new index for the diagnosis,prognosis and treatment of laryngeal carcinoma.

关 键 词：凋亡抑制因子 SURVIVIN 喉鳞癌 表达 临床分期 组织学分级 淋巴结转移 

分 类 号：R739.65[医药卫生—肿瘤]