测定β_2-微球蛋白对膀胱癌患者的临床意义  

CLINICAL SIGNIFICANCE OF BETA-2 MICROGLOBULIN IN BLADDER CANCER

作　　者：刘朝东[1] 何梓铭[1] 罗加[2] 吴国桢[2] 

机构地区：[1]重庆医科大学第一医院泌尿外科 [2]重庆医科大学核医学科

出　　处：《重庆医科大学学报》1992年第4期287-291,共5页Journal of Chongqing Medical University

摘　　要：本文报告34例膀胱癌,13例其它恶性肿瘤,15例下尿路感染,21例正常人用放射免疫法测定血、尿β_2-微球蛋白(β_2-MG)及尿/血β_2-MG比值的结果,发现膀胱癌组尿β_2-MG值显著高于其它任何一组,其增高者(>240μg/L)占79%.尿β_2-MG及尿/血β_2-MG比值随肿瘤的分期、分级增加而增高.作者讨论了影响测定β_2-MG的因素和测定β_2-MG的临床意义,认为尿β_2-MG升高可能由于肿瘤细胞释放β_2-MG到尿里.测定尿β_2-MG对诊断膀胱癌或血尿的鉴别诊断有重要意义,也可能对术前估计肿瘤的恶性程度。The urinary(U), serum(S) β2 microglobul in (β2-MG) and its U/S ratio Were studied in patients with bladder carcinoma(34), non-bladder neoplasms(13), lower urinary tract infections( 15) and normal subjects(21) by radioimmunoassay. The urinary β2-MG levels in patients with bladder carcinoma (>240 μg/L, 79%were significantly higher than other groups(P<0.01). The elevated urinary (β2-MG value corresponds to the increase in tumor stage that urinary β2-MG value elevated in bladder carcinoma were discussed. It was considered that high value of the urinary β2-MG in patients with bladder carcinoma may by released by the tumor cell itself. Therefore, the urinary β2-MG will have a practical importance in patients with bladder carcinoma or hematuria for the diagnosis and could also contribute to the biochemical monitoring of bladder carcinoma as a marker for estimating preo-peratively malignancy and detecting postoperatively recurence

关 键 词：膀胱肿瘤 Β2微球蛋白 

分 类 号：R737.140.4[医药卫生—肿瘤]