后程加速超分割放射治疗食管癌的临床研究  

Study of late course accelerated hyperfractionation radiotherapy for esophageal carcinoma

作　　者：吉林[1] 张伟[1] 杨家林[1] 赵勇[1] 文浩[1] 王冀川[1] 郎锦义[1] 

机构地区：[1]四川省肿瘤医院放疗科,四川成都610041

出　　处：《中国肿瘤临床与康复》2004年第2期142-144,共3页Chinese Journal of Clinical Oncology and Rehabilitation

摘　　要：目的 研究后程加速超分割放射治疗食管癌的疗效。方法 1997年10月～1999年10月我院治疗食管癌患者120例,随机分为两组:常规分割放疗(CFR)组60例,每天1次,每次2 Gy,每周5次,总肿瘤剂量70 Gy;后程加速超分割放疗(LCAHR)组60例,常规分割放疗40 Gy后改为每天2次,每次1.5 Gy,每次间隔6 h,每周10次,总肿瘤剂量70 Gy。结果LCAHR组和CFR组1,2,3年生存率分别为73.3％、53.3％、40.0％和63.3％、53.3％、50.0％;LCAHR组和CFR组1,2,3年局控率分别为56.6％、26.7％、16.7％和36.7％、30.0％、26.7％,两组差异有显著性(P<0.05)。结论后程加速超分割放射治疗食管癌照射方法优于常规分割放疗。患者能耐受,值得临床进一步研究。Objective To study the efficacy of late course accelerated hyperfractionation radiotherapy in treatment of esophageal carcinoma. Methods From October 1997 to October 1999,120 patients with esophageal carcinoma were randomized into two groups: late course accelerated hyperfractionation radiotherapy group(LCAHR) 60 patients and conventional fractionation radiotherapy group(CFR) 60 patients. Patients in CFR received 2 Gy per fraction,5 fractions per week with the total dose of 70 Gy; Patients in LCAHR received 1.5 Gy per fraction and two fractions per day with 6-hour interval, 10 fractions per week with the total dose of 70 Gy after 40 Gy of conventional fractionation radiotherapy.Results l-,2- and 3-year survival rates and 1-,2- and 3-year local control rates in LCAHR group were significantly higher than those in CFR group (P < 0.05), being respectively 73.3 % , 53.3 % , 40.0% vs 63. 3%, 53.3%, 50.0%; 56. 6%, 26. 7%, 16.7% vs 36. 7% , 30. 0% , 26. 7% . Conclusion LCAHR schedule for radiotherapy of esophageal carcinoma can give better survival rate than CFR. The LCAHR treatment can be tolerated by the patients and merits further study in clinical practice.

关 键 词：食管肿瘤 放射疗法 后程加速超分割 

分 类 号：R735.1[医药卫生—肿瘤] R730.55[医药卫生—临床医学]