吲哚-3-乙酸对人外周血淋巴细胞微核和SCE频率的影响  

The Effect of the Indole-3-Acetic Acid on the SCE and Micronuclei of Human Peripheral Lymphocytes

作　　者：胡晓岩[1] 黄辰[1] 宋土生[1] 王艾英[1] 

机构地区：[1]西安交通大学医学院遗传教研室,陕西西安710061

出　　处：《癌变．畸变．突变》2004年第3期171-172,共2页Carcinogenesis,Teratogenesis & Mutagenesis

基　　金：陕西省自然科学基金(No.2001SM62)

摘　　要：背景与目的 :研究吲哚_3_乙酸对人体外周血淋巴细胞微核和SCE频率的影响。材料与方法 :应用人体外周血淋巴细胞测定吲哚_3_乙酸诱导微核形成率试验和姊妹染色单体互换率(SCE)。结果 :各吲哚_3_乙酸处理组与阴性对照组相比 ,微核形成率和SCE差异均存在显著性。结论BACKGROUND&AIM: To study the effect of the indole-3-acetic acid(IAA)on the SCE and micronuclei of human peripheral lymphocytes. MATERIAL AND METHODS: We apply IAA to detect micronuclei and SCE of human peripheral lymphocytes. RESULTS: There were salience difference on the micronuclei rate and SCE rate between each group treated with different concentration of the indole-3-acetic acid and the negative controlled group(P<0.05) .CONCLUSION: The indole-3-acetic acid damaged the genetic material of human peripheral lymphocytes.

关 键 词：吲哚-3-乙酸 姊妹染色单体互换(SCE) 微核 

分 类 号：R394.2[医药卫生—医学遗传学]