Ki-67与P-GP170在甲状腺乳头状癌中的表达及临床意义  

Expressions and clinical significance of Ki-67 of and P-GP170 in thyroid papillary carcinoma

作　　者：成继民[1] 贺占国[1] 刘艳丽[1] 付红霞[2] 

机构地区：[1]解放军白求恩国际和平医院病理科,石家庄050082 [2]解放军260医院病理科,石家庄050041

出　　处：《华北国防医药》2004年第2期83-84,F003,共3页Medical Journal of Beijing Military Region

摘　　要：目的 :检测Ki 67与多药耐药蛋白P GP170在甲状腺乳头状癌和甲状腺腺瘤中的表达 ,以探讨两种基因蛋白在甲状腺乳头状癌诊断和治疗中的作用。方法 :应用免疫组织化学SP法检测Ki 67与P GP170在 90例甲状腺乳头状癌和 2 0例甲状腺腺瘤中的表达 ,并对其表达结果进行统计学分析。结果 :Ki 67在甲状腺乳头状癌中平均增殖指数为 44 0 0± 3 9 3 4,腺瘤为 16 80± 17 2 0 ,两者相差显著 (P <0 0 5 )。P GP170在甲状腺乳头状癌中阳性率为 77 78%( 70 /90 ) ,腺瘤阳性率为 5 0 0 0 %,两者相差显著 (P <0 0 5 )。Ki 67和P GP170在甲状腺乳头状癌的表达相关非常显著 (r =0 65 ,P <0 0 1)。结论 :Ki 67在甲状腺乳头状癌较腺瘤增殖指数高、耐药性强 ,检测Ki 67有助于甲状腺乳头状癌的诊断 ;甲状腺乳头状癌增殖指数与耐药性呈正相关 ,检测P GP170对指导临床的化疗具有一定意义。Objective:To investigate the expressions and clinical significance of anti nuclear antigen Ki 67 and P GP170 (P glyco protein, P GP170) in thyroid papillary carcinoma and thyroid adenoma in order to explore the significance of these two proteins in diagnosis and treatment of thyroid tumors.Methods:SP immunohistochemical technique was applied to detection of the two antigens mentioned above in 90 cases of thyroid papillary carcinoma and 20 cases of thyroid adenoma.Statistical analysis was conducted between them.Results:The average PI (proliferation index, PI) of Ki 67 was significantly higher in thyroid papillary carcinoma than that in thyroid adenoma (77 78% vs 50.00% and 44 00±39 34 vs 16 80±17 20 respectively, P <0 05).The expression of Ki 67 was notably correlated with the expression of P GP170 ( r=0 65, P <0.01) in thyroid papillary carcinoma.Conclusions:A elevated PI was found in thyroid papillary carcinoma,indicating a high expression of Ki 67 and a stronger drug resistance.Detection of Ki 67 was helpful to the diagnosis of thyroid papillary carcinoma.PI was positively correlated with drug resistance.Detection of P GP170 was significant in guidance of chemotherapy in clinical practice.

关 键 词：KI-67 P-GP170 甲状腺乳头状癌 临床意义 免疫组织化学SP法 耐药性 化疗 

分 类 号：R736.1[医药卫生—肿瘤]