溃疡性结肠炎患者血清TNF-α的变化  

Relationship between serum tumor necrosis factor-α and ulcerative colitis

作　　者：贾百灵[1] 候晓华[1] 

机构地区：[1]华中科技大学同济医学院协和医院消化科

出　　处：《第四军医大学学报》2004年第9期849-850,共2页Journal of the Fourth Military Medical University

摘　　要：目的 :测定溃疡性结肠炎 (UC)患者血清中肿瘤坏死因子 (TNF α)的含量 ,并分析其与病变范围、活动度的关系 .方法 :UC患者 5 6例 ,采用ELISA法测定血清中TNF α的含量 .正常对照组为健康体检者 .结果 :活动期UC患者TNF α含量 (2 2 7.5± 39.5 )ng/L显著高于缓解期UC患者 (1 31 .2± 37.8)ng/L及正常对照组 (1 2 0 .1± 36 .4 )ng/L(P <0 .0 1 ) .全结肠炎组TNF α为 (2 98.2± 30 .9)ng/L ,显著高于远端结肠 +直肠炎组 (1 6 6 .4± 35 .3)ng/L及左半结肠炎组 (1 5 3.8± 34.3)ng/L(P <0 .0 1 ) .结论 :UC患者血清TNF α含量与病变活动度及病变范围有关 。AIM: To determine the levels of tumor necrosis factor α(TNF α) in serum of patients with ulcerative colitis (UC) and to study the relationship between TNF α levels and the active degree and area of lesion of UC. METHODS: The sera were collected from 56 patients with UC and the level of TNF α was measured by ELISA. TNF α was also measured in normal blood donors as control. RESULTS: The levels of serum TNF α of patients with UC in active stage were (227.5±39.5) ng/L, significantly higher than those of patients with UC in inactive stage [(131.2±37.8) ng/L] and normal control [(120.1±36.4) ng/L] ( P < 0.01) . The levels of serum TNF α with whole colon disorder [(298.2±30.9) ng/L] were higher than those with rectum sigmoid lesion [(166.4±35.3) ng/L] and left colon disorder [(153.8±34.3) ng/L] ( P <0.01). CONCLUSION: The changing levels of serum TNF α may be related to the development of UC and can be used as an index for the disease.

关 键 词：结肠炎 溃疡性 肿瘤坏死因子 诊断 

分 类 号：R574.62[医药卫生—消化系统]