不同光凝接触镜填充液对中央角膜厚度的影响  

Influence of Different Interface Solutions for Corneal Contact Lens on Central Corneal Thickness

作　　者：黄渝侃[1] 王智[1] 魏厚仁[1] 

机构地区：[1]华中科技大学同济医学院附属协和医院眼科,武汉430022

出　　处：《华中科技大学学报（医学版）》2004年第2期226-228,共3页Acta Medicinae Universitatis Scientiae et Technologiae Huazhong

摘　　要：目的　比较在行氩激光全视网膜光凝治疗中使用不同接触镜填充液对中央角膜厚度的影响 ,以寻找最适用于该治疗的填充液。方法　对 4 6例 (5 2眼 )患者进行氩激光全视网膜光凝治疗 ,每次分别随机使用 0 2 5 %氯霉素、1%羧甲基纤维素及医用透明质酸钠组作为安放全眼底激光角膜接触镜填充液 ,在治疗前及治疗后均用角膜测厚仪测量患者中央角膜厚度。结果　治疗后使用 0 2 5 %氯霉素组中央角膜平均增厚 (31 4± 10 2 ) μm ,1%羧甲基纤维素组中央角膜平均增厚 (10 6± 4 3) μm ,医用透明质酸钠组中央角膜平均增厚 (8 0± 3 5 ) μm。方差分析显示 :氯霉素组与另两组差异有极显著性意义 (P <0 0 1) ,羧甲基纤维素组与透明质酸钠组差异无显著性意义 (P >0 0 5 )。结论　 1%羧甲基纤维素及医用透明质酸钠作为安放全眼底激光角膜接触镜的填充液对角膜水肿程度的影响明显小于0 2 5 %氯霉素 。Objective To compare the influence of different interface solutions on central corneal thickness in argon laser panretinal photocoagulation (PRP), and to find out the best interface solution for the treatment. Methods Fifty two eyes of 46 patients underwent the argon laser PRP for 4 times. 0 25 % cloramphenicol eye drops, 1 % carboxymethylcellulose (CMC) and sodium hyaluronate (SH) were used at randam as interface solutions respectively to install the hard corneal contact lens in the first 3 times of laser treatment. The central corneal thickness was measured before and after photocoagulation by using corneal pachymeter. Results The mean central corneal thickness was increased by (31 4±10 2) μm, (10 6±4 3) μm, and (8 0±3 5) μm respectively in the cloramphenicol group, the 1 % CMC group, and the SH group respectively. Analysis of variance revealed that there was statistically significant difference between the cloramphenicol group and the other two groups ( P <0 01), but no statistically significant difference was found between the CMC group and the SH group ( P >0 05). Conclusion 1 % CMC and SH as interface solutions to install the hard corneal contact lens for the panretinal photocoagulation have less effect on the corneal edema than 0 25 % cloramphenicol eye drops. They are two kinds of appropriate interface solutions.

关 键 词：全视网膜激光光凝疗法 接触镜 填充液 角膜水肿 透明质酸 

分 类 号：R779.63[医药卫生—眼科]