Assessment of hepatocellular carcinoma vascularity before and after transcatheter arterial chemoembolization by using first pass perfusion weighted MR imaging  

作　　者：Jun-GongZhao Gan-ShengFeng xiang-QuanKong XinLi Ming-HuaLi Ying-ShengCheng 

机构地区：[1]DepartmentofRadiology,SixthAffiliatedHospitalofShanghaiJiaotongUniversity,Shanghai200233,China [2]DepartmentofRadiology,UnionHospital,TongjiMedicalCollege,HuazhongUniversityofScienceandTechnology,Wuhan430022,HubeiProvince,China

出　　处：《World Journal of Gastroenterology》2004年第8期1152-1156,共5页世界胃肠病学杂志（英文版）

摘　　要：AIM:To assess the vascularity of hepatocellular carcinoma (HCC) before and after transcatheter arterial chemoembolization (TACE) with the quantitative parameters obtained by first pass perfusion weighted MR imaging (FP-MRI). METHODS:Seventeen consecutive patients with one to three lesions in liver underwent FP-MRI before treatment. FP-MRI was also performed one,three,six,nine months, and one year after TACE.The baseline signal intensity (SO) of pre-TACE and one month after TACE was analyzed,the vascularity of HCC assessed by steepest slope of the signal intensity versus time curves (SS) was blindly correlated with their DSA feature and clinical outcome. RESULT:No significant difference was found on baseline signal intensity (S0) between pre-TACE and one month after TACE (F=0.309,P=0.583),The SS (mean,32% per second) of lesion one month after TACE was lower than that of pre-TACE (mean,69% per second),but with no statistical significance (F=3.067,P=0.092).When local recurrence occurred,the time intensity curves became steeper.The vascularity of HCC before and after TACE graded by SS closely correlated with that by DSA (K=0.453,P<0.05). CONCLUSION:FP-MRI is a useful criterion for selecting effective interventional treatment for patients with HCC in their initial treatment and during follow up.To assess the vascularity of hepatocllular carcinoma (HCC)before and after transcatheter arterial chemoembolization(TACE) with the quantitative parameters obtained by firstpass perfusion weighted MR imaging (FP-MRI).

关 键 词：肝细胞癌 血管分布 动脉导管化疗栓塞 疗效评价 核磁共振 

分 类 号：R730.5[医药卫生—肿瘤] R735.7[医药卫生—临床医学]