微卫星DNA的多态性及其应用  

Polymorphism of macrosatellite DNA and its application

作　　者：国伟[1] 沈佐锐[1] 

机构地区：[1]中国农业大学农学与生物技术学院,北京100094

出　　处：《生物技术通讯》2004年第2期158-159,共2页Letters in Biotechnology

基　　金：国家973项目(G20000016210)子专题

摘　　要：微卫星DNA是广泛存在于各种真核生物基因组中的短串联重复序列,具有突变速率快、多态性高等特点,本文分析了微卫星的多态性及其形成机制,并简要介绍其在亲缘关系鉴定、种群遗传结构分析、基因图谱以及基因诊断等方面的应用。Microsatellite DNA, comprising short tandem repeated nucleotide sequences, is ubiquitous in eukaryotic genomes. It offers unusual advantages, such as abundant polymorphisms, rapid and convenient analysis. Here, the polymorphism mechanism of macrosatellite DNA is introduced and the latest application of microsatellite is reviewed, including its mutations, relationship identification, analysis of population genetics, microsatellite mapping and so on.

关 键 词：微卫星DNA 多态性 突变速率 基因图谱 基因诊断 亲缘关系 

分 类 号：Q74[生物学—分子生物学]