慢性癫痫对大鼠空间记忆再生能力的影响  

Influence of chronic epilepsy on spatial memory retrieval in rats

作　　者：张力三[1] 金春雷[1] 李青[2] 孙永诚[1] 陈忠[1] 

机构地区：[1]浙江大学医学院药理学教研室,浙江杭州310031 [2]浙江医学高等专科学校生理学教研室,浙江杭州310053

出　　处：《浙江大学学报（医学版）》2004年第3期205-208,共4页Journal of Zhejiang University(Medical Sciences)

基　　金：国家自然科学基金( 30 0 0 0 0 19;30 3716 38);浙江省青年人才基金( R30 3779)资助项目

摘　　要：目的 :探讨慢性癫痫对大鼠空间记忆再生能力的影响 ,检测组胺前体物质组氨酸和胆碱酯酶抑制剂TAK- 14 7对癫痫诱发记忆障碍的作用。方法 :大鼠在放射状八臂 (四臂放食物 )迷宫训练成功后 ,隔日腹腔注射亚惊厥剂量 ( 35 mg/ kg)的戊四唑 ,直至完全点燃。完全点燃后在同一迷宫中测记忆的再现过程。结果 :完全点燃后第1d至第 18d,大鼠在放射状迷宫中的错误次数较对照组明显上升 ,且维持在一相对平衡的状态 ,31d后与对照组一致。TAK- 14 7剂量依赖性地改善了癫痫诱发的空间记忆再现障碍 ,包括参考记忆和工作记忆。组氨酸剂量依赖性地改善参考记忆 ,不影响工作记忆。结论 :戊四唑点燃癫痫可导致大鼠空间记忆再生能力下降 。Objective: To investigate the influence of chronic epilepsy on spatial memory retrieval in rats, and to evaluate the effects of TAK-147, an acetylcholinesterase inhibitor, and histidine, the precursor of histamine, on the amnesia induced by epilepsy. Methods: After successfully trained in the 8-arm (4-arm baited) radial maze, the rats were ip injected with a subconvulsive dose of pentylenetetrazole (PTZ) every 48 h until fully kindled. Memory retrieval was tested at the same maze. Results: Impairment of memory retrieval was in a steady state 1 to 18 days after fully kindled, the ability of memory retrieval returned to the control level 31 days after fully kindled. TAK-147 showed an ameliorating effect on memory impairment induced by epilepsy, including reference and working memory in a dose-dependent manner. Histidine only ameliorated reference but not working memory. Conclusion: PTZ-kindled seizure impair spatial memory retrieval, which it might be due to a decrease of brain acetylcholine and histamine induced by epilepsy.

关 键 词：癫痫/化学诱导 放射状迷宫 记忆障碍 胆碱酯酶抑制剂/药理学 组氨酸/药理学 

分 类 号：R742.1[医药卫生—神经病学与精神病学]