栓塞用碘油制剂的磁共振信号特征及机制研究  

Magnetic resonance behavior of lipiodol——an experimental study

作　　者：蒋飚[1] 何伟良[1] 余日胜[1] 晁明[1] 

机构地区：[1]浙江大学医学院附属第二医院放射科,浙江杭州310009

出　　处：《浙江大学学报（医学版）》2004年第3期250-254,共5页Journal of Zhejiang University(Medical Sciences)

基　　金：浙江省卫生厅课题 ( 2 0 0 0 A115 );浙江省自然科学基金资助项目( 30 2 6 73)

摘　　要：目的 :阐明介入治疗栓塞用碘化油的 MR信号特征和肝肿瘤组织内沉积对 MR信号影响。方法 :4 0 %国产碘化油和 0 .4 8g/ ml超液态碘化油 ( UFL )分别与 76 %泛影葡胺配置成不同比例碘油乳剂 ,与性状相仿液态油制剂进行 MR信号测定。Walker- 2 5 6大鼠肝癌模型肝动脉碘化油栓塞后对照观察碘油沉积对肿瘤结节 MR信号的影响。结果 :国产碘化油和 UFL MR信号存在明显差异 ( P<0 .0 1) ,国产碘化油呈短 T1、T2 信号 ,UFL呈明显短 T1、长 T2 信号。随配置乳剂油水比下降 ,乳剂信号逐渐呈稀释剂信号特征 ( r=- 0 .95 8,P<0 .0 1)。经肝动脉碘油栓塞后 ,实验组肝脏 MR信号与对照组信号相仿 ,肝癌结节和肝内沉积高密度碘油 ( CT值 2 5 4.4～ 4 6 8.8HU)对组织MR信号无明显影响 ,而腹膜后淋巴组织内沉积碘油 ( CT值 110 9.0 HU)呈脂质信号改变 ,脂肪饱和序列可抑制其高信号。结论 :国产和进口碘化油 MR信号有明显差异 ,碘化油在体内不同的沉积分布状态其 MR信号不同 ,经肝动脉栓塞肿瘤结节内滞留碘油本身对肿瘤组织 MR信号无明显影响。Objective: To describe the characteristics of magnetic resonance (MR) signals generated by lipiodol and to assess the influence on MR imaging of hepatoma nodule. Methods: Pure lipiodol and lipiodol emulsions mixed with 76% urografin in different ratio were imaged by both CT and MR; quantitative T 1 and T 2 measurements of lipiodol were performed. Fourty-one SD rats with transplanted walker-256 sarcoma in liver were randomly divided into six groups: 0.4~0.6 ml lipiodol emulsion was infused via hepatic artery in experimental groups by means of laparotomy under celiac anesthesia. The changes in MRI signal of hepatoma nodule were observed. Results: In vitro, iodized oil demonstrated high signal on T 1-weighted images when performed at 37℃, but all could be suppressed by the fat saturation sequence, and showed very low signal on T 2-weighted images. The cha-racteristic of MR signal with ultra fluid lipiodol was different from that of iodized oil ( P <0.01), showing short T 1 and long T 2 signal; the high signal on T 1-weighted images was only partially suppressed by the fat saturation sequence. With descending ratio of lipiodol in emulsion, the signal behavior was gradually similar to urografin( r = -0 958, P <0 01). When rats were transarterially infused with emulsion, the intensity of the signal on MRI was nearly the same as that in the control rats, but when lipiodol was injected out of the hepatic artery and accumulated in lymphadenopathy, it demonstrated a signal similar to fat; the high intensity signal was maintained on T 1- weighted images and T 2-weighted images. Conclusion: There are little changes in MR signal intensity when the lipiodol is accumulated in the tumor nodules. MR behavior of lipiodol is determined by its deposit area.

关 键 词：碘化油 磁共振成像 肿瘤 实验性 

分 类 号：R735.7[医药卫生—肿瘤]