牛磺酸对烫伤大鼠血浆及心肌组织肿瘤坏死因子和血管紧张素Ⅱ含量的影响(英文)  

Effect of taurine on the content of tumor necrosis factor alpha and angiotensin Ⅱ in plasma and myocardiumof the rats following severe burns

作　　者：万福生[1] 万义福[2] 李国辉[3] 

机构地区：[1]江西医学院生化与分子生物学教研室 [2]江西省肺科医院 [3]第一附属医院烧伤中心

出　　处：《中国临床药理学与治疗学》2004年第5期519-522,共4页Chinese Journal of Clinical Pharmacology and Therapeutics

基　　金：ProjectsupportedbytheNationalNaturalScienceFoundationofChina(№ 3 0 0 60 0 2 9)

摘　　要：目的 :观察牛磺酸对大鼠严重烧伤后心肌损害的影响。方法 :用健康Wistar大鼠 ,随机分为对照组、烧伤组 (造成 30 %TBSAⅢ度烫伤 )和治疗组 (烧伤后腹腔注射牛磺酸 ,剂量 4 0 0mg·kg-1体重 )。于伤后 1、3、6、12和 2 4h检测血浆TNF α、AngⅡ和TnT含量与心肌中TNF α、AngⅡ含量。结果 :烧伤大鼠烧伤后 3h血浆cTnT呈显著升高 ,12h达峰值 ,2 4h显著高于对照组 ;烫伤后 6h血浆和心肌组织TNF α含量显著高于对照组 (P <0 .0 1) ,12h达峰值 ;伤后1h血浆AngⅡ含量呈显著升高 ,伤后 2 4h血浆及心肌中AngⅡ高于对照组 ;牛磺酸治疗组血浆cTnT、TNF α和AngⅡ水平较烧伤组均有显著性降低。血浆TNF α、AngⅡ含量与血浆cTnT变化密切相关。结论 :牛磺酸对严重烫伤后心肌损伤有较好的保护作用。AIM: To investigate the effect of taurine on myocardial injury in rats with severe burns. METHDOS: 110 healthy adult Wistar rats were randomly divided into 3 groups: the normal control (n=10,without burns),the burn group (n=50,subjected to a 30% total body surface area III degree scald injury),and the group treated with taurine (n=50),by abdominal cavity injection taurine ( 400 mg·kg -1 ) after scald injury immediately. Levels of tumor necrosis factor alpha (TNF-α),troponin (cTnT) and angiotensinⅡ (AngⅡ) in plasma and content of TNF-α,AngⅡ in myocardium were assayed at 1,3,6,12 and 24 h postburn. RESULTS: Plasma cTnT increased markedly at 3h postburn,peaking at 12 h ,and it was still higher than that of the control at 24 h postburn. TNF-α in plasma and myocardium also increased markedly at 6 h postburn,peaking at 12 h postbrun,and decreased somewhat at 24 h postburn,but it was still higher than that of the control group. Plasma AngⅡ increased significantly at 1 h postburn,peaking at 6 h postburn,and it was also higher than that of the control in plasma and myocardium at 24 h postburn. After treated with taurine,however,levels of cTnT,TNF-α and AngⅡ in plasma and myocardium decreased significantly compared with that of the burn group. Additionally,the levels of TNF-α and AngⅡ in plasma were correlated with cTnT levels. CONCLUSION: Taurine can protect myocardium from injury following severe burns.

关 键 词：烧伤 心肌损害 牛磺酸 肌钙蛋白T 肿瘤坏死因子 血管紧张素Ⅱ 

分 类 号：R644[医药卫生—外科学] R965[医药卫生—临床医学]