肺癌患者血清VEGF含量检测的临床意义  

Significance of Serum Level of Vascular Endothelial Growth Factor in Patients with Lung Carcinoma

作　　者：颜浩[1] 章培[1] 陈文彬[2] 周黎强[1] 徐淑辉[1] 

机构地区：[1]成都市第二人民医院,610017 [2]四川大学华西医院,610041

出　　处：《实用癌症杂志》2004年第2期180-183,共4页The Practical Journal of Cancer

摘　　要：目的　探讨肺癌患者血清血管内皮生长因子 (VEGF)含量变化的意义及其影响肺癌生长及转移的作用机制。方法原发性支气管肺癌 63例 ,采用免疫组化染色检测肺癌组织VEGF表达情况 ,酶联免疫吸附试验 (ELISA)测定血清VEGF含量 ,采用Kaplan Meier方法比较不同血清VEGF含量者的生存情况。 结果　肺癌患者血清VEGF含量明显高于正常对照组 ,不同性别、年龄、组织学类型、分化程度及T分期 (肿瘤原发状态 )血清VEGF含量无显著性差异 ,不同N分期 (淋巴结转移 )及临床分期间血清VEGF含量有显著性差异。肺癌患者血清VEGF含量与肺癌组织VEGF表达呈正相关。血清VEGF高含量患者生存时间明显短于血清VEGF低含量者。结论　血清VEGF与肺癌淋巴结转移及临床分期进展密切相关 ,血清VEGF含量可作为判断肺癌淋巴结转移潜能及预后评价的可靠参考指标。肺癌细胞分泌VEGF进入血液循环 。Objective To investigate the clinical value of serum level of vascular endothelial growth factor(VEGF) in patients with lung carcinoma and to evaluate the mechanism of VEGF to affect lung carcinoma growth,development and metastasis.Methods The expression of VEGF in lung carcinoma tissue was examined by immunohistochemisty in 63 patients treated with curative surgery.The serum level of VEGF was measured by enzyme-linked immunosorbent assay.The relationship between the survival time and the serum level of VEGF was analysed by the Kaplan-Meier method.Results The serum level of VEGF was significantly higher in patient with lung cancer than in control group.The serum level of VEGF had no significant relationship with the gender,age,pathologic type,differentiation and tumor factor(T).There was significant difference in serum level of VEGF between patients with different lymphatic metastasis and clinical stage.There was positive correlation between the serum level of VEGF and the expression of VEGF in lung carcinoma tissue.Survival analysis showed that the high serum VEGF was associated with a high risk of death.Conclusion VEGF plays an important role in lymphatic metastasis and lung carcinoma development.The serum level of VEGF may be an reliable predictor for prognosis.VEGF is secreted by tumor cells and subsequently released into blood.It may be the mechanism of VEGF to promote tumor growth and metastasis.

关 键 词：肺癌 血清学检查 血管内皮生长因子 免疫组化法 肿瘤转移 预后 血管形成 

分 类 号：R734.2[医药卫生—肿瘤]