高-低氧放疗对小鼠小肠上皮放射效应的影响  

Effects of carbogen plus low concentration oxygen radiotherapy on murine intestinal epithelium

作　　者：梁军[1] 赵建东[1] 

机构地区：[1]青岛大学医学院附属医院肿瘤科,266003

出　　处：《中华放射医学与防护杂志》2004年第1期34-36,共3页Chinese Journal of Radiological Medicine and Protection

基　　金：青岛科学技术委员会基金资助项目 (2 0 0 0 2 8)

摘　　要：目的　观察X射线照射时 ,给予高 低氧对小鼠小肠上皮生物效应的影响。方法　昆明小鼠随机分为空气组、高氧组、低氧组、高 低氧组。用 6MVX射线不同剂量全腹腔单次照射。配合剂量效应曲线 ,求出不同吸氧方式的放射防护系数 (RPF)。结果　高氧组、低氧组RPF分别为0 79,1 2 5。高 低氧组照射表现出一定的放射防护作用 ,其RPF为 1 0 6。结论　高 低氧放疗消除了碳合氧吸入加重的小肠上皮的放射损伤 ,在一定程度上还具有放射防护作用。Objective To investigate the effects of carbogen plus low concentration oxygen radiotherapy on murine intestinal epithelium. Methods Kun Ming mice were divided into four groups:Air,HO,LO and HO+ LO.The abdomen of mice was irradiated with 6 MV X-rays at different single doses.The relationship between total cell survival per circumference and radiation dose was established,and dose-survival curves were fitted.Radioprotective factors(RPFs) were calculated. Results The RPF of groups HO,LO and HO+LO was 0.79,1.25 and 1.06,respectively. Conclusion Inhalation of low concentration oxygen can eradicate the enhanced damage by carbogen and possesses certain radioprotective effect. ;

关 键 词：小肠上皮 生物效应 X射线 吸氧方式 放射损伤 

分 类 号：R73-36[医药卫生—肿瘤]