食管癌患者放疗前后TNF水平的变化及其意义  

Investigation of Serum TNF in Patients with Esophageal Carcinoma before and after Radiotherapy

作　　者：汪涛[1] 杨迁[1] 薛文华[1] 张钰頔[1] 

机构地区：[1]西安交通大学第一医院肿瘤放疗科,西安710061

出　　处：《陕西医学杂志》2004年第5期401-403,共3页Shaanxi Medical Journal

摘　　要：目的 :探讨肿瘤坏死因子 ( TNF)在食管癌患者放疗前后的水平变化 ,以及TNF与食管癌不同病理类型和分级、病变长度、有无锁骨上淋巴结转移及近期疗效的关系。方法 :对 84例食管癌患者放疗前后及 2 8例健康人血清 TNF水平进行检测。结果 :食管癌患者放疗前血清 TNF水平 1 .91± 0 .48ng/ml( 92 .8% ) ,明显高于放疗后 1 .67± 0 .46ng/ml( 85 .7% )及对照组 0 .85± 0 .1 6ng/ml( 7.1 % ) ( P<0 .0 1 ) ;TNF水平变化与不同病理类型、病理分级、有无锁骨上淋巴结转移无关 ,和病变长度及近期疗效有关。结论 :TNF作为一种肿瘤标志物 ,对食管癌的诊断。Objective: To investigate the serum levels of tumor necrosis factor (TNF) in patients with esophageal carcinoma and evaluate the relationship between TNF and the pathologic type and clinic features. Methods: The serum levels of TNF were measured by radioimmunoassay(RIA) method in 28 cases of healthy controls and 84 cases of patients with esophageal carcinoma before and after radiotherapy. Results:In patients with esophageal carcinoma before radiotherapy, the levels of TNF were 1.91±0.48ng/ml(92.8%), which were much higher that the levels of TNF after radiotherapy 1.67±0.46ng/ml(85.7%)(P<0.01) and the than those of control (0.85±0.16ng/ml) (P<0.01). The TNF levels were correlated with the length of the lesion and the response to radiotherapy. Conclusion: Serum TNF was a useful marker for esophageal carcinoma in diagnosis and evaluation of the response to radiotherapy.

关 键 词：食管癌 放疗 TNF 肿瘤坏死因子 

分 类 号：R735.1[医药卫生—肿瘤]