血管内皮生长因子和转化生长因子β_1在眼眶海绵状血管瘤的表达及意义  

The expression and significance of VEGF and TGF-β_1 in orbital cavernous hemangioma

作　　者：易伟华[1] 魏锐利[1] 蔡季平[1] 李玉莉[2] 

机构地区：[1]中国上海第二军医大学附属长征医院眼科,200003 [2]中国上海第二军医大学附属长征医院病理科,200003

出　　处：《国际眼科杂志》2004年第2期247-249,共3页International Eye Science

基　　金：中国上海市科委科研项目资助课题(No.0352nm114)

摘　　要：目的:研究血管内皮生长因子(VEGF)和转化生长因子β1(TGF-β1)在眼眶海绵状血管瘤(OCH)中的表达及意义。方法:1998/2003OCH的标本25例,取体表海绵状血管瘤(CVM)病理标本和正常小静脉(口径200～500μm)各25例,采用Envision法免疫组化染色观察血管内皮生长因子(VEGF)和转化生长因子β1(TGF-β1)的表达,半定量分析结果。结果:VEGF在OCH、CVM和正常小静脉中都有阳性表达,CVM中VEGF的表达明显强于OCH。TGF-β1在OCH、CVM和正常小静脉中都无阳性表达。结论:VEGF表达变化可能是OCH形成发展的重要因素,也是其与CVM大体表现不同的重要病理因素之一。TGF-β1对OCH的发生可能不起主要作用。AIM: To study the expression and significance of VEGF and TGF-β1 in orbital cavernous hemangioma.· METHODS: Tissue samples were taken from 25 cases of orbital cavernous hemangioma, 25 cases of cavernous venous malformation of the body surface and 25 specimens of small vein. Envision immunohistochemistry stain was used to observe the expression of VEGF and TGF-β1. The results were analyzed semi-quantitatively.· RESULTS: VEGF expression in cavernous venous malformation was obviously stronger than that in orbital cavernous hemangioma. There was no difference on the expression of TGF-β1.· CONCLUSION: The abnormal expression of VEGF may be an important factor in etiopathology and progress of orbital cavernous hemangioma.·

关 键 词：血管内皮生长因子 转化生长因子Β1 眼眶海绵状血管瘤 临床意义 免疫组织化学 

分 类 号：R739.7[医药卫生—肿瘤]