奥扎格雷钠治疗急性脑梗死的疗效观察  

The Observation of therapeutic effect of sodium ozagrel in the treatment of acute cerebral infarction

作　　者：赵喜才[1] 王艳辉[1] 王文辉 彭小祥 

机构地区：[1]黑龙江省大庆市第四医院神经内科,163712 [2]大庆市萨中卫生所 [3]湖北省中山医院神经内科

出　　处：《中国脑血管病杂志》2004年第5期216-217,220,共3页Chinese Journal of Cerebrovascular Diseases

摘　　要：目的 了解奥扎格雷钠治疗急性脑梗死的临床疗效,并分析其相关实验室指标的变化。 方法 选用一般情况具有可比性的急性脑梗死患者,将其随机分成两组,治疗组49例,对照组50例。治疗组的患者给予奥扎格雷钠80 mg+5％葡萄糖500 ml静脉滴注,每天2次;给予对照组患者低分子右旋糖酐。 结果 治疗组患者治疗后血小板聚集率降低、纤维蛋白原含量较治疗前降低,差异有显著性意义。对照组患者此两项指标治疗前后变化无显著性意义。两组患者的治疗结果:治疗组显效率为73.4％,对照组为36％(P<0.01);治疗组有效率为91.8％,对照组为68％(P<0.01)。结论 奥扎格雷钠治疗急性脑梗死的临床疗效是肯定的,他能使急性脑梗死患者血液中的血小板聚集率降低、使血液中的纤维蛋白原含量降低;使急性脑梗死患者临床症状显著改善,即实验室所获得数据的改变与临床症状改善是同步的。Objective To study the clinical efficacy of sodium ozagrel in the treatment of acute cerebral infarction and to analysie the related changes of laboratory index. Methods Two groups of patients who had acute cerebral infarctions with comparative conditions were randomly divided into a therapeutic group (49 cases) and a control group (50 cases). The patients of the therapeutic group were given sodium ozagrel 80mg dissolved in 5% glucose solution 500ml twice a day intravenously, and in the control group were given low molecular weight dextran. The data obtained from the two groups were analyzed with a test. Results Both the platelet aggregation rate and blood fibrinogen content were lower in the therapeutic groups; as for the clinical symptoms, the notable and effective results in the therapeutic group were 73. 4% and 91. 8% while those in the control group were 36% and 68% respectively, which were significantly lower than those in the therapeutic group. Conclusion The therapeutic effects of sodium ozagrel were obvious in the treatment of acute cerebral infarction, and the platelet aggregation rate and fibrinogen content also reduced in blood. The clinical symptoms were significantly improved in the patients of the therapeutic group and the laboratory datum also proved the results.

关 键 词：奥扎格雷钠 药物治疗 急性脑梗死 静脉滴注 低分子右旋糖酐 

分 类 号：R743.33[医药卫生—神经病学与精神病学]