活血化瘀方对高脂饮食致家兔动脉粥样硬化的影响  

Effects of the Five Recipes for Promoting Blood Circulation for Removing Blood Stasis against Acheriosclerosis Induced by High Lipid Diet in Rabbits

作　　者：周小青[1] 罗尧岳[1] 谢小兵[1] 刘建新[1] 

机构地区：[1]湖南中医学院,湖南长沙410007

出　　处：《中国中医药信息杂志》2004年第5期401-403,共3页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：教育部青年骨干教师科研基金资助项目(200065)

摘　　要：目的 探讨五首活血化瘀方对高脂喂饲家兔动脉粥样硬化(AS)的影响。方法 采用高脂喂饲复制家兔动脉粥样硬化模型,观察各组家兔血脂、载脂蛋白、血液流变学改变。结果 血府逐瘀汤组家兔血清TC、LDL-c明显低于丹参饮组、桃红四物汤组(P<0.01),血清TC/HDL-c明显低于丹参饮组、失笑散组、桃红四物汤组(P<0.01),血清TG低于丹参饮组(P<0.05),血清TG/HDL-c比值低于丹参饮组、失笑散组、活络效灵丹组(P<0.01);血清apoB100低于失笑散组、桃红四物汤组(P<0.05);血浆粘度明显低于活络效灵丹组、桃红四物汤组(P<0.01),全血粘度(低切、高切)明显低于失笑散组(P<0.01);活络效灵丹组家兔血清TC、LDL-c低于丹参饮组、桃红四物汤组(P<0.05),血清TC/HDL-c明显低于丹参饮组、桃红四物汤组(P<0.01),亦低于失笑散组(P<0.05);家兔血清apoB100低于丹参饮组、失笑散组、桃红四物汤组(P<0.05),血清apoA1/apoB100比值高于丹参饮组、失笑散组、桃红四物汤组(P<0.05);丹参饮组家兔全血粘度(低切、高切)明显低于失笑散组(P<0.01),红细胞比容低于桃红四物汤组(P<0.05);桃红四物汤组血清TG低于丹参饮组(P<0.05),血清TG/HDL-c低于丹参饮组、失笑散组(P<0.05),全血粘度(低切、高切)低于失笑散组(P<0.05)。结论 五首活血化瘀方均可不同?Objective To study the effect of five promoting blood circulation for removing blood stasis recipes against atheriosclerosis in rabbits and distinguish the similaries and differences of the five recipes. Methods The models were developed by feeding high cholesterol diet, the changes of serum lipid and apoprotein and hemorheoloy were detected. Results Xuefuzhuyutong (XFZYT) was more effective to decrease the levels of TC, LDL-c, TC/HDL-c in serum than Danshenyin (DSC), Taohongsiwutong (THSWT) (P<0.01), it was also more effective to decrease the levels of TG/HDL-c in serum than DSY, Shi xiao san (SXS), to decrease the levels of apoB100 in serum than SXS, THSWT (P<0.05), to decrease plasma viscosity than Huoluoxiaolingdan (HLXLD), THSWT (P<0.01), to decrease whole blood viscosity than SXS (P<0.01). HLXLD was more effective to decrease the levels of TC, LDL-c (P<0.05), TC/HDL-c (P<0.01) in serum than DSY, THSWT. It was also more effective to decrease the levels of apoB100 and increase the ratio of apoA1 and apoB100 than DSY, SXS, THSWT (P<0.05). DSY was more effective to decrease whole blood viscosity than SXS (P<0.01), it was also more effective to decrease hematocrit than THSWT (P<0.05). THSWT was more effective to decrease the levels of TG, TG/HDL-c in serum than DSY, SXS. It was also more effective to decrease TG/HDL-c in serum and whole blood viscosity than SXS (P<0.05). Conclusion The five recipes can modulate the lipid and apoprotein metabolism and to improve hemorheoloy and to prevent the development of the acheriosclerosis in varying degrees. XFZYT is more effective than HLXLD, DSY, THSWT, SXS.

关 键 词：活血化瘀方 高脂饮食 家兔 动脉粥样硬化 血液流变学 AS 

分 类 号：R259.435[医药卫生—中西医结合]