单药泰索帝治疗晚期乳腺癌每周方案与每3周方案疗效及毒性比较  

COMPARATION OF EFFICACY AND TOXICITY WITH TAXOTERE GIVEN WEEKLY OR EVERY THREE WEEKS IN ADVANCED BREAST CANCER

作　　者：刘芳[1] 江泽飞[1] 宋三泰[1] 刘晓晴[1] 闫敏[1] 郝春芳[1] 张少华[1] 王涛[1] 孙君重[1] 张志强[1] 申戈军 

机构地区：[1]事医学科学院307医院乳癌内科,北京100039

出　　处：《肿瘤研究与临床》2004年第2期94-96,共3页Cancer Research and Clinic

摘　　要：目的:分析单药泰索帝治疗晚期乳腺癌每3周方案与每周方案疗效与毒性的关系.方法:33例晚期乳腺癌患者.其中12例患者接受每3周方案,剂量范围为70.7mg/m2～86.1mg/m2,中位剂量为75 mg/m2;20例患者接受每周方案,剂量范围为20.4 mg/m2～28.7mg/m2,中位剂量为25 mg/m2.结果:本组患者的总有效率为25.0%,其中软组织、肺、骨及肝脏有效率分别为60%、23.1%、21.4%和27.8%;既往应用过蒽环类的患者有效率为25.0%,既往应用过紫杉醇的患者有效率27.3%;每3周方案与每周方案疗效均为25.0%,两者之间无统计学差异;每3周方案的Ⅲ度～Ⅳ度白细胞毒性大,而每周方案白细胞毒性轻,耐受性良好.结论:单药泰索帝治疗晚期乳腺癌疗效肯定.对老年、一般状况差及部分难治性乳腺癌患者仍有疗效,每周方案更易被耐受.Objective: To evaluate the relation of efficacy and toxicity in advanced breast cancer treated with taxotere as a single agent given weekly or every three weeks. Methods: 33 patients with advanced breast cancer were studied. 12 patients were given at a dose of 70.7 mg/m2~ 86.1 mg/m2 every three weeks, and 21 patients were given at a dose of 20.4 mg/m2~28.7 mg/m2 weekly. Efficacy and toxicity was evaluated. Results: The overall response rate in this group of advanced breast cancer was 25.0 %. Responses were seen in soft tissue, lungs , bone and liver, and the response rates were 60 %,27.8 %,21.4 %,23.1 %, respectively. The treatment response rates were 25.0 % in prior anthracycline- pretreated patients and 27.3 % in taxane-pretreated patients. Compared with three- weekly administered of taxotere, response rates were all 25.0 %. There were no significant difference between the two groups. Grade 3- 4 WBC toxicity was found in all cycles when Taxotere was given three times weekly, but taxotere was generally well tolerated. Conclusion: Taxotere as a single agent therapy is effective. Weekly taxotere therapy is well tolerated by elderly and /or poor- performance status patients and/or heavily pretreated patient with advanced breast cancer.

关 键 词：晚期乳腺癌 泰索帝 疗效 毒性 

分 类 号：R737.9[医药卫生—肿瘤] R730.53[医药卫生—临床医学]