12-钨硼酸5-氟尿嘧啶盐的合成及抗癌活性研究  

Synthesis and Anti-liver Cancer Activity of 5-Fluorouracil Salt of 12-Tungstoboric Acid

作　　者：李娟[1] 李静[2] 齐燕飞[1] 王宏芳[2] 王恩波[1] 胡长文[1] 许林[1] 吴新宇[2] 

机构地区：[1]东北师范大学化学学院多酸化学研究所,长春130024 [2]吉林大学公共卫生学院,长春130021

出　　处：《高等学校化学学报》2004年第6期1010-1012,共3页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金 (批准号 :2 0 1710 10 )资助

摘　　要：5-Fluorouracil salt(WBF) of 12-tungstoboric acid with Keggin structure was synthesized and its structure was characterized by IR, 1H NMR, 183 W NMR and elementary analysis. The MTT experimental results show that WBF has a stronger killing ability for liver cancer cells in vitro. The acute toxicity of WBF was carried out. The half toxicity dose LD_ 50 of WBF orally administrated to mice is 1 117.4 mg/kg. [WT5HZ]5-Fluorouracil salt(WBF) of 12-tungstoboric acid with Keggin structure was synthesized and its structure was characterized by IR, 1H NMR, 183 W NMR and elementary analysis. The MTT experimental results show that WBF has a stronger killing ability for liver cancer cells in vitro. The acute toxicity of WBF was carried out. The half toxicity dose LD_ 50 of WBF orally administrated to mice is 1 117.4 mg/kg. [WT5HZ]

关 键 词：钨硼酸 5-氟尿嘧啶 合成 抗癌活性 

分 类 号：O614[理学—无机化学]