动脉持续灌注罂粟碱对兔脑血管痉挛的实验研究  

Experimental study on the effects of continuous intraarterial infusion papaverine to cerebral vasospasm in rabbits

作　　者：芦奕[1] 孙丕通[2] 惠国桢[1] 白景阳[2] 许友松[2] 吴智远[1] 

机构地区：[1]苏州大学附属第一医院神经外科,215006 [2]大连医科大学附属第一医院神经外科

出　　处：《江苏医药》2004年第5期334-336,M004,共4页Jiangsu Medical Journal

摘　　要：目的　观察动脉持续灌注罂粟碱对蛛网膜下腔出血后脑血管痉挛的作用。方法　日本大耳白兔用“二次枕大池注血法”制作症状性脑血管痉挛模型。经一侧椎动脉用微量泵持续灌注罂粟碱。结果　持续灌注罂粟碱 2天、5天基底动脉造影直径和神经系统损害症状级别与治疗前比较有明显改善 (P <0 0 1) ;对照组无明显改善 (P >0 0 5 )。对照组基底动脉、脑组织结构改变明显 ,治疗组基本正常。结论　动脉持续灌注罂粟碱有预防迟发性脑血管痉挛作用。Objective To observe the effects on continuous intraarterial infusion papaverine to cerebral vasospasm following experimental subarachnoid hemorrhage.Methods The models of Japanese rabbits with symptomatic cerebral vasospasm were established by blood injection of twice cisternal magna.Via one side vertebral artery,papaverine was continuously infused by a mini pump.Results After continuous intraarterial infusion of papaverine for 2 days and 5 days,each of the angiographic diameter of basilar artery and the grade of neurological deficit in treatment group improved more obviously than those before treatment( P< 0.01);there was no obvious change in the control group( P> 0.05).There was marked change in the structure of basilar artery and brain in the control group.However there was no obvious change in the treatment group.Conclusion The continuous intraarterial infusion papaverine has preventive effects in delayed cerebral vasospasm.

关 键 词：蛛网膜下腔出血 脑血管痉挛 罂粟碱 动物实验 神经系统损害 动脉造影 

分 类 号：R743.35[医药卫生—神经病学与精神病学]