草酸铂联合羟基喜树碱、氟脲嘧啶、甲酰四氢叶酸钙治疗晚期胃癌36例的疗效观察  

Clinical Research of Oxaliplatin in Combination With HCPT、LV and 5Fu Regimen for Advanced Gastric Cancer

作　　者：胡国清[1] 付强[1] 金懋林 沈琳 李杰[3] 潘良熹[4] 白玉贤 王怀瑾 张健伟[7] 于丁[8] 

机构地区：[1]华中科技大学同济医学院附属同济医院肿瘤中心,武汉市430030 [2]北京大学临床肿瘤学院 [3]上海第二医科大学新华医院肿瘤科 [4]江苏省肿瘤医院内科 [5]黑龙江省肿瘤医院内科 [6]大连市肿瘤医院 [7]北京军区总医院肿瘤科 [8]湖北省肿瘤医院内科

出　　处：《中国肿瘤临床》2004年第9期506-508,512,共4页Chinese Journal of Clinical Oncology

摘　　要：目的:观察舍草酸铂和羟基喜树碱的联合化疗方案治疗晚期胃癌的近期疗效及不良反应.方法:化疗方案(OHLF3方案):草酸铂130mg/m2,静滴,第1日;羟基喜树碱6mg/m2,静滴,第1～5日;甲酰四氢叶酸钙200mg/m2,静滴2小时,第1～3日;5-氟脲嘧啶400mg/m2,快速静注,追加600mg/m2,持续静滴22小时,第1～3日,每21日为一周期,完成3周期后判定疗效,有效病例4周后确认.结果:全组39例患者,实际可评价疗效患者36例,总有效率(CR+PR)为50%(1818/36);主要不良反应为轻度的血液学毒性、恶心呕吐和外周感觉神经异常.结论:含草酸铂和羟基喜树碱的OHLF3方案是治疗晚期胃癌有效且毒性较小的联合化疗方案.Objectives: To observe the effects and adverse reactions of OXA-HCPT LV/5Fu3 regimen for patients with advanced gastric cancer. Methods: OHLF3 regimen: OXA 130mg/m2 iv d1,HCPT 6mg/m2 iv d1-5, LV 200mg/ m2 iv 2h followed by 5-Fu 400mg/ m2 iv bolus and 5-fu 600mg/m2 iv d1-3 were given, and every 21 days as 1 cycle.Tumor assessment was done after 3 cycles and the effective cases were confirmed after 4 weeks. Results: Among 39 patients, 36 ones were actually evaluable. Overall response rates(CR+PR) were 50%; the major adverse reaction are mild hematology toxicity, nausea and vomiting and abnormal perisensory nerve. Conclusion: OHLF3 regimen involved OXA and HCPT is an effective and mild toxicity combined chemotherapy for advanced gastric cancer.

关 键 词：草酸铂 羟基喜树碱 晚期胃癌 OHLF3方案 氟脲嘧啶、甲酰四氢叶酸钙 疗效 化疗 

分 类 号：R735.2[医药卫生—肿瘤]