对Hazelton等提出的云锡矿工肺癌主要危险来自砷的商榷  

High attributable risk due to arsenic for lung cancer in Yunnan tin mine reported by WD Hazelton et al

作　　者：孙世荃[1] 

机构地区：[1]中国辐射防护研究院,太原030006

出　　处：《中华放射医学与防护杂志》2004年第2期184-186,共3页Chinese Journal of Radiological Medicine and Protection

摘　　要：Using two-stage clonal expansion model with data-base provided by Lubin,WD Hazelton et al indicated the high risk of arsenic,but not radon,in the etiology of Yunnan tin miner’s lung cancer.The author of this review iterated the problems in the data-base of Lubin,and considered that it may result in low estimate for the risk of radon in paper of Hazelton et al.Attributable risk was estimated by them with changing exposure patterns of each individual,but the efficacy of this two-stage model will be violated by the invariability of appointed radon/arsenic exposures.Risk comparison was used to distinguish the contribution from radon/arsenic,which was hampered by the high correlation between their joint exposures.As Lubin,Hazelton et al neglected the confounding from environmental arsenic pollution in early years.From all of above,their viewpoint is worth to be deliberated.Using two-stage clonal expansion model with data-base provided by Lubin,WD Hazelton et al indicated the high risk of arsenic,but not radon,in the etiology of Yunnan tin miner's lung cancer.The author of this review iterated the problems in the data-base of Lubin,and considered that it may result in low estimate for the risk of radon in paper of Hazelton et al.Attributable risk was estimated by them with changing exposure patterns of each individual,but the efficacy of this two-stage model will be violated by the invariability of appointed radon/arsenic exposures.Risk comparison was used to distinguish the contribution from radon/arsenic,which was hampered by the high correlation between their joint exposures.As Lubin,Hazelton et al neglected the confounding from environmental arsenic pollution in early years.From all of above,their viewpoint is worth to be deliberated.

关 键 词：矿工 肺癌 砷 危险因素 水污染 

分 类 号：R734.2[医药卫生—肿瘤]