Plasma erythropoietin levels in anaemic and non-anaemic patients with chronic liver diseases  

作　　者：Cosimo MarcelloBruno Sergio Neri ClaudioSciacca Gaetano Bertino Pietro DiPrima Danila Cilio Luciano Caruso Raffaello Cristaldi Rinaldo Pellicano 

机构地区：[1]Department of Internal Medicine and Sistemic Diseases,University of Catania,Italy [2]Department of Gastro-Hepatology,Molinette Hospital,Torino,Italy

出　　处：《World Journal of Gastroenterology》2004年第9期1353-1356,共4页世界胃肠病学杂志（英文版）

摘　　要：AIM: To investigate the serum erythropoietin (Epo) levels in patients with chronic liver diseases and to compare to subjects with iron-deficiency anaemia and healthy controls.METHODS: We examined 31 anaemic (ALC) and 22 non-anaemic (NALC) cirrhotic patients, 21 non-anaemic subjects with chronic active hepatitis (CAH), 24 patients with iron-deficiency anaemia (ID) and 15 healthy controls. Circulating Epo levels (ELISA; R&D Systems, Europe Ltd, Abingdon,UK) and haemoglobin (Hb) concentration were determined in all subjects.RESULTS: Mean±SD of Epo values was 26.9±10.8 mU/mL in ALC patients, 12.5±8.0 mU/mL in NALC subjects,11.6±6.3 mU/mL in CAH patients, 56.4±12.7 mU/mL in the cases of ID and 9.3±2.6 mU/mL in controls. No significant difference (P>0.05) was found in Epo levels between controls, CAH and NALC patients. ALC individuals had higher Epo levels (P<0.01) than these groups whereas ID subjects had even higher levels (P<0.001) than patients suffering from ALC.CONCLUSION: Increased Epo values in cirrhotics, are only detectable when haemoglobin was lesser than 12 g/dL.Nevertheless, this rise in value is lower than that observed in anaemic patients with iron-deficiency and appears blunted and inadequate in comparison to the degree of anaemia.AIM:To investigate the serum erythropoietin (Epo) levels in patients with chronic liver diseases and to compare to subjects with iron-deficiency anaemia and healthy controls. METHODS:We examined 31 anaemic (ALC) and 22 non- anaemic (NALC) cirrhotic patients,21 non-anaemic subjects with chronic active hepatitis (CAH),24 patients with iron- deficiency anaemia (ID) and 15 healthy controls.Circulating Epo levels (ELISA;R&D Systems,Europe Ltd,Abingdon, UK) and haemoglobin (Hb) concentration were determined in all subjects. RESULTS:Mean±SD of Epo values was 26.9±10.8 mU/mL in ALC patients,12.5±8.0 mU/mL in NALC subjects, 11.6±6.3 mU/mL in CAH patients,56.4±12.7 mU/mL in the cases of ID and 9.3±2.6 mU/mL in controls.No significant difference (P>0.05) was found in Epo levels between controls,CAH and NALC patients.ALC individuals had higher Epo levels (P<0.01) than these groups whereas ID subjects had even higher levels (P<0.001) than patients suffering from ALC. CONCLUSION:Increased Epo values in cirrhotics,are only detectable when haemoglobin was lesser than 12 g/dL. Nevertheless,this rise in value is lower than that observed in anaemic patients with iron-deficiency and appears blunted and inadequate in comparison to the degree of anaemia.

关 键 词：Aged Anemia  Iron-Deficiency ERYTHROPOIETIN Female HEMOGLOBINS Hepatitis  Chronic Humans Liver Cirrhosis Male Middle Aged Regression Analysis 

分 类 号：R575[医药卫生—消化系统]