胃幽门螺杆菌感染清除后黏膜病理的动态变化  

Dynamic changes of gastric mucosal pathology after clearance of Helico-bacter pylori infection

作　　者：徐翠兰[1] 王琳[2] 赵丽华[1] 李军[1] 

机构地区：[1]威海市立医院病理科,山东省威海市264200 [2]威海市立医院内科,山东省威海市264200

出　　处：《世界华人消化杂志》2004年第5期1092-1095,共4页World Chinese Journal of Digestology

基　　金：山东省科技厅计划项目;No.2000(69)~~

摘　　要：目的:探讨幽门螺杆菌(简称Hpylori)在胃部感染经抗Hpylori 药物治疗后,黏膜病变的病理变化规律. 方法:应用电子胃镜或手术标本取胃黏膜行病理观察,抗H pylori规范治疗组(n=32)和非抗H pylori规范治疗组(n=25)对照,间隔6 mo,1 a随诊再次取材行胃黏膜组织学检查,并做对比分析. 结果:在Hpylon感染治疗组32例中胃Hpylori数量减少或消失,胃黏膜病变(炎症、肠化及异型增生)均有不同程度的好转,各组问差异均有显著性(P<0.05).未经抗Hpylori 治疗组25例,H pylori数量及胃黏膜病变变化不明显, 无统计学意义(P>0.05).治疗组与对照组重度病变对比分析有统计学意义(P<0.05). 结论:抗Hpylori感染治疗对胃黏膜组织学病变的好转有着积极的意义;而未经系统抗Hpylori治疗组胃黏膜病变有待进一步研究.AIM: To investigate the characteristics of pathological changes in the gastric mucosa after anti-Helicobacter pylori (H pylori) therapy. METHODS: The samples were obtained through electronic gastroscope or operation and divided into two groups: therapy group (n=32) in which the patients received standard anti-H pylori therapy; and control group (n=25) without anti-H pylori therapy. Histological examinations were carried out after gastroscopic inspection or operation, half a year and one year later. RESULTS: H pylori in the mucous membrane of the stomach in all 32 cases in therapy group diminished or disappeared and pathological changes (inflammation, intestinal metaplasia and dysplasia) attenuated to some extent. There were significant differences between samples at different time points of examination (P<0.05). In all 25 cases in group control, changes of Hpylori and pathology of the mucous membrane were not apparent. There was not a stalistical significance between samples at different time points of examination (P>0.05). There was significant difference between samples of therapy and control groups (P<0.05). CONCLUSION: Anti-H pylori therapy has active significance for the improvement of pathological changes in the mucous membrane of the stomach.

关 键 词：胃黏膜 幽门螺杆菌 细菌感染 病理学 胃镜 

分 类 号：R573[医药卫生—消化系统]