口腔鳞癌α-catenin和β-catenin的表达与颈淋巴转移研究  

Correlation Study on Neck Lymph Node Metastasis and α-Catenin,β-Catenin Expression in Oral Squamous Cell Carcinoma Tissue

作　　者：谭学新[1] 宫相芹[2] 王大仁[1] 王玉新[1] 王绪凯[1] 

机构地区：[1]中国医科大学附属第一医院口腔颌面外科,辽宁沈阳110001 [2]沈阳市口腔医院特诊科,辽宁沈阳110002

出　　处：《微生物学杂志》2004年第3期16-18,共3页Journal of Microbiology

摘　　要：采用蛋白杂交技术 ,对 6 8例口腔癌中的α catenin和 β catenin蛋白表达进行了研究 ,探讨其表达与口腔癌颈淋巴结转移的相关性 ,发现与未发生淋巴结转移的口腔鳞癌相比 (32 ) ,淋巴结转移的口腔鳞癌组织中(36 ) ,α catenin和 β catenin蛋白表达出现明显的降低 (P <0 .0 1 )。此结果提示了口腔鳞癌淋巴结转移与α catenin和 β catenin蛋白表达的丧失是密切相关 。Correlation between neck lymph node metastasis (NLNM) and αcatenin,βcatenin expression in oral squamous cell carcinoma (OSCC) was studied through samples from 68 cases by protein hybridization adopting Western blotting to detect the expression level of αcatenin and βcatenin. As compared with OSCC without NLNM (32 cases), the expression level of αcatenin and βcatenin in OSCC with NLNM (36 cases) lowered apparently (P<0.01). These results suggested that there is close correlation between NLNM of OSCC and the loss of αcatenin and βcatenin expression. And it can be valuable in determination of the development possibility of the tumor metastasis and judging indices after recover.;

关 键 词：口腔鳞癌 淋巴结转移 Α-CATENIN Β-CATENIN 

分 类 号：R782.2[医药卫生—口腔医学]