大豆异黄酮对大鼠体内SOD、CAT和NO的影响  

Influence of soybean isoflavone on SOD,CAT and NO of Wistar rats

作　　者：庄颖[1] 姚荣英[1] 孟灿[1] 韩慧[1] 赵文红[1] 李威[1] 

机构地区：[1]蚌埠医学院卫生学教研室,安徽蚌埠233003

出　　处：《蚌埠医学院学报》2004年第3期205-206,共2页Journal of Bengbu Medical College

基　　金：蚌埠医学院科研项目 (by0 3 0 6)

摘　　要：目的 :以喂养高胆固醇饲料造成高脂血症 (HC)的大鼠为研究对象 ,观察大豆异黄酮 (SI)对大鼠体内过氧化状态的影响。方法 :5 0只Wistar大鼠随机分为 5组 ,分别接受基础饲料、高脂饲料、高脂饲料分别添加SI 30mg/kg、90mg/kg和 2 70mg/kg处理。实验 7周。 结果 :SI中、低剂量组与高脂组和SI高剂量组比较有抑制超氧化物歧化酶、过氧化氢酶的体内过氧化作用 (P <0 .0 1 ) ,而高脂组和SI剂量组无此作用 (P >0 .0 5 ) ;SI实验组血清中的一氧化氮 (NO)水平低于对照组 (P <0 .0 5 ) ,而组织中的NO水平高于对照组 (P <0 .0 5～P <0 .0 1 )。结论 :SI能改善高脂所致体内异常的过氧化状态 。Objective:To observe the influence of soybean isoflavone(SI) on the lipid peroxidation in Wistar rats.Methods:Fifty Wistar rats were randomly divided into five groups and fed on foundation feed,high fat feed and high fat feed mixed with 30 mg/kg,90 mg/kg and 270 mg/kg SI respectively.The experiment lasted for 7 weeks.Results:SI at low dose level had preventive effect on the rise of lipid peroxidation induced by high fat feed( P <0.01),but SI at high dose level did not( P >0.05).experiment groups had lower level of NO in the serum and higher level in the tissue than the control( P <0.05～ P <0.01).Conclusions:SI can improve the abnormal oxidation caused by high fat feed,alleviate the lesion due to peroxidation,and influence the NO level in the serum.

关 键 词：大豆异黄酮 脂质过氧化 一氧化氮 超氧化物歧化酶类 过氧化氢酶类 大鼠 

分 类 号：S565.1[农业科学—作物学] Q591.5[生物学—生物化学]