血管NAD(P)H氧化酶在血管重塑中的作用  

Role of vascular NAD(P)H oxidase in vascular remodeling

作　　者：陈闻东[1] 高平进[1] 朱鼎良[1] 

机构地区：[1]上海市第二医科大学上海市高血压研究所,上海200025

出　　处：《中国病理生理杂志》2004年第5期896-899,903,共5页Chinese Journal of Pathophysiology

基　　金：国家重点基础研究发展规划项目 (No .G2 0 0 0 0 5 6 90 4 )

摘　　要：NAD(P)H oxidase was initially found in phagocytes and it participates in the generation of reactive oxygen species(ROS). Recent researches have showed that NAD(P)H oxidase also expresses in other tissues including blood vessels and it plays a critical role in vascular remodeling through ROS which are important signaling molecules in vascular cells.This article reviews the biochemical characterization, activation paradigms, structure, and function of this enzyme.NAD(P)H oxidase was initially found in phagocytes and it participates in the generation of reactive oxygen species(ROS). Recent researches have showed that NAD(P)H oxidase also expresses in other tissues including blood vessels and it plays a critical role in vascular remodeling through ROS which are important signaling molecules in vascular cells.This article reviews the biochemical characterization, activation paradigms, structure, and function of this enzyme.

关 键 词：NADPH氧化酶 活性氧 血管重塑 

分 类 号：R363[医药卫生—病理学]