吸入麻醉药镇痛、催眠作用与GABA_A受体的关系  

The relationship between the analgesic and hypnotic effects of volatile anesthetic and GABA_A receptor

作　　者：颜梅[1] 戴体俊[2] 

机构地区：[1]徐州医学院药理学教研室,徐州221002 [2]徐州医学院麻醉学系,徐州221002

出　　处：《中国药理学通报》2004年第5期521-523,共3页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助课题;No 3 9970 715;江苏省自然科学基金资助课题;NoBK2 0 0 114 3

摘　　要：目的　分析吸入麻醉药安氟醚、异氟醚和七氟醚催眠、镇痛作用与GABAA 受体的关系。方法　建立小鼠催眠、镇痛模型后 ,在小鼠催醒、热板、扭体实验中 ,分别观察用药后小鼠翻正反射消失持续时间、痛阈或扭体次数的变化。结果　一叶秋碱和荷包牡丹碱对上述 3种吸入麻醉药的催眠、镇痛作用的影响均无显著性 (P >0 0 5 )。结论　GABAA 受体并非安氟醚、异氟醚和七氟醚催眠。AIM To study the relationship between the analgesic and hypnotic effects of enflurane, isoflurane and sevoflurane and GABA A receptor. METHODS After having established the mice model of analgesics and hypnotics, we injected the mice with GABA A-receptor antagonist and observed changes of sleep time using awaken test, pain threshold hot-plate test and writhing times writhing test. RESULT Securinine and bicuculline had no distinctive effects to the three volatile anesthetics mentioned above (P>0.05). CONCLUSION GABA A receptor may not be the major target of enflurane, isoflurane and sevoflurane.

关 键 词：吸入麻醉药 催眠 镇痛 一叶秋碱 荷包牡丹碱 GABAA受体 

分 类 号：R-332[医药卫生] R329.24