大蒜素对抗癌药物作用的初步研究  

A STUDY OF ALLITRIDUM IN COMBINATION WITH CHEMOTHERAPEUTIC AGENTS AS CHEMOSENSITIZER

作　　者：陆婉琴[1] 金杏泉[1] 徐静芳[1] 

机构地区：[1]上海医科大学肿瘤医院临床药理室

出　　处：《肿瘤》1992年第3期113-115,F003,共4页Tumor

摘　　要：采用小鼠肉瘤180(S_(180))和人体肿瘤细胞株(人红白血病、K_(562)),观察了大蒜素对顺氯氨铂(DDP)、环磷酰胺(CYT)、5-氟脲嘧啶(5-Fu)、米托蒽醌等抗癌药物的增敏作用。体外实验结果表明:不同浓度的大蒜素(0.001～500mg/L)对人红白血病K_(562)细胞有明显抑制作用,与对照组比较,P<0.001。体内实验结果表明:一次腹腔给予大蒜素(50～200mg/L),除对CYT有些增敏作用外,对上述其它抗癌药并不起增敏作用。而连续给子大蒜素d_(1-?),对抗癌药有增敏作用。提示:适当调整抗癌药物和大蒜素的剂量,同时增加大蒜素给药次数,就可能使大蒜素发挥很好的作用。Allitridum (Alt) has been studied as a chemosensitizer in mouse S_(180) in vivo andhuman leukemia K_(562) in vitro. The results showed that Alt (0.001-500mg/L) hadremarkable activity of growth inhibition on K_(562) in vitro, (P<0.001), anf that Alt(50-200mg/kg i.p.× d_1) combined with CYT seemed to have antitumor activity betterthan CYT used (60mg/kg i.p.×d_1) alone in ascitic S_(180)-bearing mice. When Alt (50-200mg/kg i.p.×d_(1-9)) used in combination with DDP (2.5mg/kg i.p.×d_1), the resultalso showed an enhancement of DDP antitumor activity.

关 键 词：大蒜 大蒜素 抗癌 

分 类 号：R282.710.5[医药卫生—中药学]