恶性肿瘤患者T细胞亚群和SIL-2R的变化及意义  

Detection of T cell subsets and SIL-2R in patients with malignant tumors

作　　者：卢香兰[1] 李霞[1] 王萍萍[1] 李玲[2] 李艳[1] 

机构地区：[1]中国医科大学附属第一医院血液科,辽宁沈阳110001 [2]辽宁省人民医院检验科

出　　处：《中国医科大学学报》2004年第3期243-244,共2页Journal of China Medical University

摘　　要：目的 :探讨恶性肿瘤患者T细胞亚群及可溶性白细胞介素 2 (SIL 2R)的变化。方法 :采用APAAP法检测恶性肿瘤患者CD3、CD4、CD8细胞 ,采用ELISA法测定血清SIL 2R的含量。结果 :恶性肿瘤患者的CD3、CD4、CD4 /CD8明显降低 ,SIL 2R明显升高 ,与正常对照组相比差异显著。手术后CD3、CD4、CD4 /CD8升高 ,SIL 2R下降 ,与对照组相比无统计学意义。发生癌转移的患者 ,除CD3、CD4、CD4 /CD8明显降低外 ,CD8明显升高。结论 :恶性肿瘤患者免疫功能低下 ,尤其是发生癌转移的患者 ,免疫功能更低。手术切除肿瘤组织使免疫功能紊乱得以纠正。Objective: To investigate the variation of T cell subsets and soluble interleukin 2 recepter(SIL 2R) in patients with malignant tumors. Methods:Using APAAP method, the T cell subsets were determined. The serum level of SIL 2R was measured with ELISA method. Results:The CD3,CD4,CD4/CD8 were significantly lower and the SIL 2R was obviously higher in patients than those in the control group. After operation, the CD3,CD4,CD4/CD8 increased and the SIL 2R decreased. With metastasis the CD8 was obviously higher. Conclusion:The immunity function of the patients was significantly lower, especially in those with metastasis. After operation, the disturbance of immunity function of the patients can be regulated.

关 键 词：恶性肿瘤 T细胞亚群 可溶性白细胞介素2 

分 类 号：R730.23[医药卫生—肿瘤]