影响动物肠道SI基因表达的因素  

Factors that influence the expression of sucrase-isomaltase (SI) gene

作　　者：付亮剑[1] 孙建义[1] 陈艳[1] 许梓荣[1] 

机构地区：[1]浙江大学动物分子营养学教育部重点实验室,浙江杭州310029

出　　处：《浙江农业学报》2004年第3期167-171,共5页Acta Agriculturae Zhejiangensis

摘　　要：Sucrase isomaltase(SI,蔗糖酶异麦芽糖酶复合物,EC3.2.1.48-10),是动物体内很重要的二糖酶,位于小肠刷状缘细胞膜上。SI合成的前体是分子量为260kD左右的肽链,加工成熟后同时具有蔗糖酶和异麦芽糖酶活性。SI对碳水化合物的消化起重要作用。小肠肠道中SI含量受多种因素的影响,它们主要是通过调节SI基因的表达得以实现。本文综述了SI基因的特点以及碳水化合物、激素对其表达的影响。因SI基因是只在肠上皮细胞中表达的,所以对SI的研究有助于我们了解小肠酶的合成分化情况以及肠道特异基因表达的模式。Sucrase-isomaltase (SI,EC 3.2.1.48-10) is an important disaccharidase ,lies in intestinal brush border membrane. SI precursor is a single chain of approximately 260 000 daltons. The mature SI includes sucrase and isomaltase that have biological activity. SI plays important roles in carbohydrate digestion. The content of SI in intestine is affected by many factors, which modulate the expression of SI gene. This article mainly reports the characteristics of SI gene and effects of carbohydrate and hormones on the expression of SI gene .SI gene is a specific gene that expressed only in enterocytes, so the study on SI gene can help us to understand the synthesis and differentiation of enzymes in small intestine and the model for investigation of intestine-specific gene expression.

关 键 词：SI 基因 表达 时空 碳水化合物 激素 

分 类 号：Q344.13[生物学—遗传学]