皮肤鳞状细胞癌和基底细胞癌组织中β-转化生长因子1及受体1表达  

The expression of transforming growth factor-β1 and its type-1 receptor in cutaneous squamous cell carcinomas and basal cell carcinomas

作　　者：马泽粦[1] 樊翌明[1] 吴志华[1] 李顺凡[1] 

机构地区：[1]广东医学院附属医院皮肤科,广东湛江524001

出　　处：《临床皮肤科杂志》2004年第5期269-271,共3页Journal of Clinical Dermatology

基　　金：湛江市科技攻关基金资助项目湛科(2003)69-7

摘　　要：目的:观察皮肤鳞状细胞癌(SCC)和基底细胞癌(BCC)组织中β-转化生长因子1(TGF-β1)及其受体1(TβR-Ⅰ)表达与临床、组织病理特征的关系。方法:应用ABC免疫组化技术检测48例皮肤SCC和41例BCC手术切除标本中TGF-β1和TβR-Ⅰ的表达。结果:SCC中TGF-β1、TβR-Ⅰ表达明显高于BCC(P<0.05);高分化SCC中TβR-Ⅰ表达明显上调(P<0.05),但TGF-β1表达与肿瘤分化程度无关(P>0.05)。SCC和BCC中TGF-β1与TβR-Ⅰ的表达呈显著正相关(r=0.739,P<0.001;r=0.716,P<0.001),但其与患者性别、年龄、病程、发病部位、病灶、淋巴结转移及BCC侵袭性无关(P>0.05)。结论:TGF-β1表达与肿瘤分化程度、侵袭性及淋巴结转移无关。Objectives: To study the expressions of transforming growth factor-β1 (TGF-β1) and type-1 TGF-β receptor (TβR-I), and their relationships to clinicopathological characteristics in cutaneous squamous cell carcinomas (SCC) and basal cell carcinomas (BCC). Methods: The expression of TGF-β1 and TβR-I was determined by ABC immunohistochemical technique in 48 cutaneous SCCs and 41 BCCs. Results: The expression of TGF-β1 and TβR-1in SCCs was significantly higher than that in BCCs (P < 0.05). TβR-1 expression in well differentiated SCCs was upregulated compared with the poorly differentiated one (P < 0.05), but TGF-β1 expression was not related to the histological grade (P > 0.05). Although significantly positive correlation was observed between the expression of TGF-β1 and TβR-I in SCCs (r=0.739,P < 0.001) and in BCCs (r=0.716,P < 0.001), their expression was not correlated with sex, age, course of diseases, tumor location, primary or metastasic tumors, lymph node metastasis and aggressiveness of BCC (P > 0.05) in SCCs and BCCs. Conclusions: The expression of TGF-β1 may not be related to tumor differentiation, aggressiveness and lymph node metastasis.

关 键 词：癌 鳞状细胞 癌 基底细胞 β-转化生长因子Ⅰ 免疫组化 

分 类 号：R739.5[医药卫生—肿瘤]