垂体腺瘤中MMP-9及TIMP-1表达与肿瘤生物学行为的关系  

Correlation of expression of MMP-9 and TIMP-1 with biological behaviors in pituitary adenomas

作　　者：王震[1] 吕长虹[1] 司海鹏[1] 李圆圆[1] 

机构地区：[1]重庆医科大学病理学教研室

出　　处：《临床与实验病理学杂志》2004年第2期200-202,共3页Chinese Journal of Clinical and Experimental Pathology

摘　　要：目的　探讨MMP 9及其抑制因子TIMP 1在垂体腺瘤中表达与肿瘤生物学行为的关系。方法　应用免疫组化S P法检测上述基因蛋白在 2 3例侵袭性和 2 4例非侵袭性垂体腺瘤组织中的表达。结果　侵袭性垂体腺瘤组中MMP 9的表达和MMP 9表达超过TIMP 1的比例高于非侵袭性腺瘤组 (P <0 0 5 ) ;TIMP 1在侵袭性垂体腺瘤组的表达有降低的趋势 ,但无统计学意义 (P >0 0 5 ) ;MMP 9与TIMP 1表达呈正相关 (P <0 0 5 )。结论　MMP 9表达上调导致其和TIMP 1的表达失衡与垂体腺瘤侵袭性有关 ,MMPPurpose To study the correlation of expression of MMP-9 and TIMP-1 with biological behaviors in pituitary adenomas. Methods The expression of MMP-9 and TIMP-1 was determined by immunohistochemical S-P method in 23 case of invasive adenomas and 24 non-invasive adenomas. Results The invasive group had a significantly higher expression of MMP-9 and proportion of MMP-9/TIMP-1 expression more than that of non-invasive group (P<0.05). A significant difference was not found for expression of TIMP-1 between two groups(P>0.05), but there was a positive relation between expression of MMP-9 and TIMP-1(P<0.05). Conclusions Imbalance of expression between MMP-9 and TIMP-1 deriving from overexpression of MMP-9 is positively related to invasiveness of pituitary adenomas. MMP-9 can be taken as a molecular biological indicator to evaluate its invasive potential.

关 键 词：垂体腺瘤 MMP-9 TIMP-1 生物学行为 免疫组化 检测 

分 类 号：R736.4[医药卫生—肿瘤]