血管内皮生长因子受体KDR在大肠癌发展中的作用  

Role of vascular endothelial growth factor and its receptor KDR in the progression of colorectal carcinoma

作　　者：雷雯[1] 张丽华[1] 张文竹[1] 吴湘如[1] 张忠德[1] 

机构地区：[1]福建省立医院肿瘤科,福州350001

出　　处：《中华普通外科杂志》2004年第3期160-162,共3页Chinese Journal of General Surgery

摘　　要：目的探讨血管内皮细胞生长因子 (vascularendothelialgrowthfactor,VEGF)受体KDR和血管生成与大肠癌发展的关系。方法应用免疫组织化学技术 ,检测 10 2例大肠癌组织KDR及VEGF蛋白表达和微血管密度 (microvesseldensity ,MVD) ,分析KDR、VEGF和MVD及其与大肠癌组织学分级、浸润深度、Dukes分期、淋巴结转移、肝转移和预后的关系。结果KDR及VEGF阳性者MVD值显著高于阴性者 (F =7 6 3及F =6 38,P <0 0 1)。KDR、VEGF表达和MVD与大肠癌Dukes分期 (χ2 =4 0 373,χ2 =39 6 3,F =10 89)、淋巴结转移 (χ2 =2 7 83,χ2 =2 1 70 ,F =5 94 )和肝转移 (χ2 =13 5 3,χ2 =8 6 8,F =6 82 )密切相关 (P <0 0 1) ,KDR及VEGF表达阳性或高MVD的大肠癌患者 5年生存率较低 (χ2 =5 7 94 ,χ2 =39 84 ,F =8 86 ,P <0 0 1)。结论KDR及VEGF与大肠癌的血管生成密切相关 ,对大肠癌的生长和浸润转移有促进作用 ,KDR、VEGF和MVD可作为反映大肠癌生物学行为的客观指标。Objective To investigate vascular endothelial growth factor (VEGF),its receptor KDR and angiogenesis in relation to progression of colorectal carcinoma (CC). Methods KDR,VEGF protein expression and microvessel density (MVD) in 102 cases of human CC were examined by immunohistochemical staining. MVD,KDR and VEGF expression were analysed with their relation to histological grade,depth of invasion,Dukes stage,lymph node metastasis,liver metastasis and prognosis of CC. Results MVD was significantly higher in KDR and VEGF-positive CC than in KDR and VEGF-negative CC ( P <0.01). KDR,VEGF and MVD positively correlated with Dukes stage ( P <0.01) ,lymph node metastasis ( P <0.01) and liver metastasis ( P <0.01). The five-year-survival rate was significantly lower in CC patients with positive expression of KDR,VEGF or high MVD. Conclusion KDR and VEGF is highly correlated to angiogenesis of CC and promotes growth,invasion and metastasis of CC. KDR and VEGF expression or MVD is one of the important predictors of the biological behavior of CC.

关 键 词：血管内皮生长因子受体 KDR 大肠癌 免疫组织化学 检测 微血管密度 

分 类 号：R735.34[医药卫生—肿瘤]