降钙素基因相关肽免疫反应纤维在大鼠心肌内的分布和密度  

Distribution and density of calcitonin gene-related peptide-like immunoreactivity fibers in myocardium of rats

作　　者：张云芳[1] 李玉兰[1] 刘慧冬[1] 李益民[1] 李晓冬[1] 赵玲辉[1] 刘颖[1] 

机构地区：[1]哈尔滨医科大学解剖学教研室,150086

出　　处：《中国地方病学杂志》2004年第3期219-220,共2页Chinese Jouranl of Endemiology

基　　金：黑龙江省科委攻关课题(GC02C144-03)

摘　　要：目的观察降钙素基因相关肽免疫反应(CGRP鄄IR)纤维在大鼠心肌内的分布和密度,为心肌病的研究奠定形态学基础。方法用免疫组织化学法显示大鼠心肌内的CGRP鄄IR纤维,计算其分布密度。结果在心房肌内和心室肌内均可见CGRP鄄IR纤维分布于心肌纤维之间,心房肌内CGRP鄄IR 纤维的面积密度和数量密度均高于心室肌。结论CGRP鄄IR 纤维在大鼠心肌内分布广泛,其分布密度存在部位差异。Objective To study the distribution and density of calcitonin gene-related peptide-like immunoreactivity(CGRP-IR) fibers in myocardium of rats and lay the morphological base for the study of myocardial diseases. Methods The immunohistochemical staining was used to show the positive fibers of CGRP-IR and calculate the density of CGRP-IR fibers in myocardium of rats. Results There were CGRP-IR positive fibers in both atrium myocardium and ventricle myocardium. On the section of atrium and ventricle myocardium, we saw the deep brown positive CGRP-IR fibers, which scattered among working myocardium fibers as fine terminal fibers. The density of CGRP-IR positive fibers in atrium myocardium was higher than that in ventricle myocardium. Conclusions CGRP-IR fibers exist in both atrium and ventricle myocardium and there is position difference in the distribution of never fibers in myocardium of rats.

关 键 词：降钙素基因相关肽 免疫反应 大鼠 心肌纤维 免疫组织化学 

分 类 号：R541[医药卫生—心血管疾病]