磁性微粒栓塞肝癌临床与病理分析  

A Clinicopathologic Study of Magnetic Microsphere Embolization for Hepatic Carcinoma

作　　者：程新宝[1] 袁曙光[2] 阎东[2] 

机构地区：[1]郑州市第五人民医院,河南郑州450003 [2]昆明医学院附属二院,云南昆明650101

出　　处：《肿瘤学杂志》2004年第3期162-164,共3页Journal of Chinese Oncology

基　　金：河南省科技成果三等奖

摘　　要：[目的]观察磁性微粒(Fe3O4)栓塞肝癌临床及病理变化,探讨其动脉栓塞作用疗效。[方法]Fe3O4微粒栓塞66例肝癌患者,其中8例栓后手术切除,标本HE染色切片。[结果]临床观察栓后综合征不明显,血生化检查显示肝、肾功能变化轻微,血清AFP多数明显下降(P<0.05)。栓后1个月CT、USG、DSA复查肿瘤明显缩小。病理检查镜下见血管内栓塞颗粒呈“筛网状”结构,其中血栓形成并机化,肿瘤组织坏死彻底。[结论]Fe3O4微粒具有缓慢栓塞血管作用,能明显减少栓后并发症。To investigate clinical and pathologic effects of magnetic microsphere (Fe3O4) embolization for hepatic carcinoma. Sixty-six patients were embolized by using microsphere (Fe3O4) under fluoroscopy with catheters. Operation was perpormed with tissue slice HE staining in 8 cases after embolism. Syndromes caused by embolism were not observed remarkably. Examination of blood biochemistry showed mild change of liver and kidney function. AFP decreased significantly after embolism in most primary hepatic carcinoma(P<0.05). Most patients were reexamined after one month by CT, USG or DSA. Tumor volume decreased markedly. Necrosis of cancer tissue was observed under pathological examination in every case. [Conclusion] Fe3O4 is slow releasing embolic substance and can reduce some complications by embolism.

关 键 词：磁性微粒 栓塞 肝肿瘤 病理学 

分 类 号：R735.7[医药卫生—肿瘤] R815[医药卫生—临床医学]